This is an old revision of this page, as edited by AndrewWatt (talk | contribs) at 00:28, 4 February 2005. The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.
Revision as of 00:28, 4 February 2005 by AndrewWatt (talk | contribs)(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff)
Duloxetine hydrochloride (brand name: Cymbalta) is a medically used drug that primarily targets major depressive disorders (MDD) and stress urinary incontinence (SUI). Known also as LY248686, chemically (+)-(S)-N-methyl-3-(1-naphthyloxy)-2-thiophenepropanamine, it is a potent dual inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE) reuptake, possessing comparable affinities in binding to NE and 5-HT transport sites. Interestingly, its behavior contrasts to most other dual-reuptake inhibitors.
Furthermore, duloxentine lacks affinity for monoamine receptors within the central nervous system. While there is limited data available regarding the pharmacokinetic profile of duloxetine in humans, its half-life is reported to be 10 to 15 hours.
External Links
 | This medical article is a stub. You can help Misplaced Pages by expanding it. |
 | This chemistry-related article is a stub. You can help Misplaced Pages by expanding it. |