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USP1
Identifiers
Aliases	USP1, UBP, ubiquitin specific peptidase 1
External IDs	OMIM: 603478; MGI: 2385198; HomoloGene: 2528; GeneCards: USP1; OMA:USP1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p31.3 Start 62,436,297 bp End 62,451,804 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 C6 Start 98,812,047 bp End 98,823,780 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte ventricular zone sperm trabecular bone ganglionic eminence gonad endothelial cell germinal epithelium cartilage tissue tibia Top expressed in seminiferous tubule gastrula primitive streak spermatid spermatocyte vas deferens mandibular prominence abdominal wall ureter maxillary prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cysteine-type peptidase activity protein binding hydrolase activity thiol-dependent deubiquitinase cysteine-type endopeptidase activity peptidase activity Cellular component nucleus nucleoplasm Biological process skeletal system development monoubiquitinated protein deubiquitination response to UV ubiquitin-dependent protein catabolic process proteolysis cellular response to DNA damage stimulus protein deubiquitination DNA repair regulation of DNA repair interstrand cross-link repair Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7398 230484 Ensembl ENSG00000162607 ENSMUSG00000028560 UniProt O94782 Q8BJQ2 RefSeq (mRNA) NM_003368 NM_001017415 NM_001017416 NM_001301414 NM_146144 NM_001356424 RefSeq (protein) NP_001017415 NP_001017416 NP_003359 NP_001288343 NP_666256 NP_001343353 Location (UCSC) Chr 1: 62.44 – 62.45 Mb Chr 4: 98.81 – 98.82 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase 1 is an enzyme that in humans is encoded by the USP1 gene.

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins.

The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized.

Therapy

USP1 expression is deregulated in certain types of human cancer. Recent findings indicated that USP1 inhibition may contribute to revert cisplatin resistance in an in vitro model of non-small cell lung cancer (NSCLC), which supports that USP1 can act as an effective target in cancer therapy.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000162607 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000028560 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
6. ^ "Entrez Gene: USP1 ubiquitin specific peptidase 1".
7. García-Santisteban, Iraia; Peters, Godefridus J.; Giovannetti, Elisa; Rodríguez, Jose Antonio (2013-08-10). "USP1 deubiquitinase: cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy". Molecular Cancer. 12 (1): 91. doi:10.1186/1476-4598-12-91. ISSN 1476-4598. PMC 3750636. PMID 23937906.{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: unflagged free DOI (link)

Further reading

• D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337–52. doi:10.1080/10409239891204251. PMID 9827704.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Fujiwara T, Saito A, Suzuki M, et al. (1999). "Identification and chromosomal assignment of USP1, a novel gene encoding a human ubiquitin-specific protease". Genomics. 54 (1): 155–8. doi:10.1006/geno.1998.5554. PMID 9806842.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Nijman SM, Huang TT, Dirac AM, et al. (2005). "The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway". Mol. Cell. 17 (3): 331–9. doi:10.1016/j.molcel.2005.01.008. hdl:1874/17796. PMID 15694335.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

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