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CX157

Clinical data
Routes of administration	Oral
ATC code	none
Legal status
Legal status	In general: uncontrolled
Identifiers
IUPAC name 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathiine 10,10-dioxide
CAS Number	205187-53-7
PubChem CID	18687754
ChemSpider	13701383
UNII	O6L62LZJ0Q
CompTox Dashboard (EPA)	DTXSID40174517
Chemical and physical data
Formula	C14H8F4O4S
Molar mass	348.27 g·mol
3D model (JSmol)	Interactive image
SMILES FC(F)(F)COc2cc3Oc1cc(F)ccc1S(=O)(=O)c3cc2
InChI InChI=1S/C14H8F4O4S/c15-8-1-3-12-10(5-8)22-11-6-9(21-7-14(16,17)18)2-4-13(11)23(12,19)20/h1-6H,7H2 Key:PDIMOTRDGUQMNY-UHFFFAOYSA-N
(verify)

CX157 (proposed trade name TriRima, formerly Tyrima) is a selective and reversible inhibitor of MAO-A (RIMA). As of 2007 it was in phase II clinical trials for the treatment of depression. In 2013, work on the drug was terminated.

References

1. Fielding R, Mielach F, Free J, Pande A (2007). Pharmacokinetics and oral bioavailability of CX157, a reversible selective MAO-A inhibitor, in primates (PDF). 2007 AAPS Annual Meeting & Exposition. Archived from the original (PDF) on 2011-05-26. Retrieved 2009-06-14.
2. Clinical trial number NCT00739908} for "A Study of CX157 (TriRima) for the Treatment of Depression (CX157-200)" at ClinicalTrials.gov

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• Reversible inhibitors of MAO-A
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