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7-Methylguanosine

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7-Methylguanosine
Names
IUPAC name 7-Methylguanosin-7-ium
Systematic IUPAC name 2-Amino-9--7-methyl-6-oxo-6,9-dihydro-1H-purin-7-ium
Other names N7-Methylguanosine; 2-Amino-1,6-dihydro-7-methyl-6-oxo-9-β-D-ribofuranosylpurinium
Identifiers
CAS Number
3D model (JSmol)
Abbreviations m7G; mG
ChEBI
ChemSpider
PubChem CID
UNII
InChI
  • InChI=1S/C11H15N5O5/c1-15-3-16(8-5(15)9(20)14-11(12)13-8)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2-,12,13,14,20)/p+1/t4-,6-,7-,10-/m1/s1Key: OGHAROSJZRTIOK-KQYNXXCUSA-O
  • InChI=1/C11H15N5O5/c1-15-3-16(8-5(15)9(20)14-11(12)13-8)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2-,12,13,14,20)/p+1/t4-,6-,7-,10-/m1/s1Key: OGHAROSJZRTIOK-UJMNIJGGBX
SMILES
  • O=C3/N=C(/N)Nc1c3n(c12O((O)2O)CO)C
Properties
Chemical formula C11H16N5O5
Molar mass 298.279 g·mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). ☒N verify (what is  ?) Infobox references
Chemical compound

7-Methylguanosine (mG) is a modified purine nucleoside. It is a methylated version of guanosine and when found in human urine, it may be a biomarker of some types of cancer. In the RNAs, 7-methylguanosine have been used to study and examine the reaction evolving methylguanosine. It also plays a role in mRNA as a blocking group at its 5´-end.

See also

References

  1. Reynaud, C; Bruno, C; Boullanger, P; Grange, J; Barbesti, S; Niveleau, A (1992). "Monitoring of urinary excretion of modified nucleosides in cancer patients using a set of six monoclonal antibodies". Cancer Letters. 61 (3): 255–62. doi:10.1016/0304-3835(92)90296-8. PMID 1739950.

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