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Zinc Finger Protein 816 (ZNF816) is a protein encoded by the ZNF816 gene, located on chromosome 19 in humans.
Gene
The ZNF816 gene is located on the minus-strand of chromosome 19, cytogenetic band 19q13.41. It spans 35,746 base pairs, from 52,927,135 to 52,962,881, containing 5 exons.
Transcripts
ZNF816 has three transcript variants, the longest is 2,711 base pairs, with 5 exons. The other two have 4 exons, while all three isoforms encode 651 amino acids. The molecular weight and isoelectric point is consistent across all three variants.
| Isoform number | AC# | mRNA length (base pairs) | Exons | AC# | Protein Length (Amino Acids) | MW | pI |
| 1 | NM_001031665 | 2711 | 5 | NP_001026835 | 651 | ~75 kDa | ~9 |
| 2 | NM_001202456.3 | 2570 | 4 | NP_001189385 | 651 | ~75 kDa | ~9 |
| 3 | NM_001202457.3 | 2560 | 4 | NP_001189386.1 | 651 | ~75 kDa | ~9 |
Proteins
The product protein of the ZNF816 gene is 651 amino acids in length, with a predicted molecular weight of 75.7 kDa and an isoelectric point of 9.44.
Domains
ZNF816 has a Krüppel-associated box, which is characterized by a KRAB domain and an array of fifteen C2H2 Zinc fingers. This domain suppresses transcription by recruiting co-repressor proteins, which create heterochromatin and block RNA polymerase from accessing the gene. The amino acid sequence includes six disordered regions, and eight protein binding sites.
Structure
The secondary structure of ZNF816
- Secondary structure (NOT from secondary structure prediction tools. Instead,
the most confident secondary structures predicted by AlphaFold & iTasser.
- 3° and 4° structure (disulfide bonds , topology within membrane
Gene Level Regulation
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Protein Level Regulation
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Homology/Evolution
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Interacting Proteins
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Clinical Significance
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References
- ^ "ZNF816 zinc finger protein 816 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-12-13.
- Yang, Peng; Wang, Yixuan; Macfarlan, Todd S. (2017-11-01). "The Role of KRAB-ZFPs in Transposable Element Repression and Mammalian Evolution". Trends in Genetics. Transposable Elements. 33 (11): 871–881. doi:10.1016/j.tig.2017.08.006. ISSN 0168-9525.