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Revision as of 22:33, 17 December 2024 by Jesswade88 (talk | contribs) (STARTED PAGE)(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff)| Johanna Joyce | |
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| Alma mater | University of Cambridge Trinity College Dublin |
| Scientific career | |
| Institutions | University of Lausanne Sloan-Kettering Institute University of California, San Francisco University of Cambridge |
| Thesis | Molecular genetic analysis of Beckwith-Wiedemann syndrome (1999) |
Johanna Joyce is an oncology researcher and Professor at the University of Lausanne. Her research considers the mechanism by which the tumour microenvironment regulates the development of cancer. She is President Elect of the European Association for Cancer Research, a Fellow of the American Association for Cancer Research and a member of European Molecular Biology Laboratory. She was awarded the 2020 Swiss Academy of Medical Sciences Robert Bing Prize in Neuroscience.
Early life and education
Joyce was born in London but grew up in Dublin. She credits her high school teachers for her inspiration to study science. She completed her undergraduate degree at Trinity College Dublin. She moved to the University of Cambridge for her doctoral research, where she investigated Beckwith–Wiedemann syndrome. She moved to the University of California, San Francisco for a postdoctoral fellowship with Douglas Hanahan. In 2004 Joyce joined the Memorial Sloan Kettering Cancer Center.
Research and career
Joyce was made an Assistant Professor at the Weill Cornell Graduate School of Medical Sciences in 2005. Here she spent her time studying tumor-associated macrophages. She spent her time outside the lab teaching at City University and New York University. She was promoted to Associate Professor in 2010, and full Professor in 2014. She moved to the University of Lausanne in 2016. Here she became a Professor of Oncology at Ludwig Cancer Research and Executive Director of the Agora Cancer Cetnre.
Her research considers the tumour microenvironment and the influence of non-cancerous immune and stromal cells. She has shown that normal tissue cells send regulatory signals to cancer cells, and that these signals can enhance tumour malignancy. She uses this insight to develop new therapies that are targeted toward the tumour microenvironment. Her research showed that targeting macrophages that promoted cancer (tumor-associated macrophages) with an inhibitor of the CSF-1 receptor did not deplete the macrophages, but changed their function, making them cancer fighters. She looked at how tumor-associated macrophages are impacted by radiotherapy, showing it could drive therapy resistance and trigger glioma growth.
Joyce has studied the complex microenvironment of brain tumours, including functional studies of preclinical models. She has studied the role of extra-intestinal microbiota in brain metastasis, and how bacterial depletion impacts brain metastasis. Her research described the phenotypes of many immune cells in the brain, as well as endothelial and mural cells in tumour vasculature.
Awards and honours
- 2007 Geoffrey Beene Junior Faculty Chair
- 2011 Boyer Young Investigator Award
- 2016 Women in Science Switzerland Annual Symposium
- 2017 Elected Fellow of European Academy of Cancer Sciences
- 2017 Women in Cancer Research Award
- 2017 Elected Member of the European Molecular Biology Organisation
- 2018 Cloëtta Prize
- 2020 Robert Bing Prize in Neuroscience
- 2022 Mark Foundation for Cancer Research ASPIRE Award
- 2022 Metastasis Research Society Fidler Award in Innovation
- 2023 Pezcoller-Marina Larcher Fogazzaro-EACR Women in Cancer Research Award
- 2024 Elected Academy Fellow of American Association for Cancer Research
- 2024 Cell Press 50 Scientists that Inspire
- 2024 President-Elect of European Association for Cancer Research
Select publications
- Quail DF; Joyce JA (November 2013). "Microenvironmental regulation of tumor progression and metastasis". Nature Medicine. 19 (11): 1423–37. doi:10.1038/NM.3394. ISSN 1078-8956. PMC 3954707. PMID 24202395. Wikidata Q29615504.
- Joyce JA; Pollard JW (April 2009). "Microenvironmental regulation of metastasis". Nature Reviews Cancer. 9 (4): 239–52. doi:10.1038/NRC2618. ISSN 1474-175X. PMC 3251309. PMID 19279573. Wikidata Q29547660.
- Stephanie M Pyonteck; Leila Akkari; Alberto J Schuhmacher; et al. (22 September 2013). "CSF-1R inhibition alters macrophage polarization and blocks glioma progression". Nature Medicine. 19 (10): 1264–1272. doi:10.1038/NM.3337. ISSN 1078-8956. PMC 3840724. PMID 24056773. Wikidata Q34993852.
References
- ^ "Ludwig Cancer Research". Retrieved 2024-12-17.
- ^ "For cancer biologist Johanna Joyce, teaching is essential to being a well-rounded scientist". www.cell.com. Archived from the original on 2024-11-26. Retrieved 2024-12-17.
- search.worldcat.org https://search.worldcat.org/en/title/894602282. Retrieved 2024-12-17.
{{cite web}}: Missing or empty|title=(help) - ^ "Johanna Joyce". CHUV. Retrieved 2024-12-17.
- "Professor Johanna Joyce | Cancer Grand Challenges". www.cancergrandchallenges.org. Retrieved 2024-12-17.
- "Professor Johanna Joyce, Researcher". Unthinkable. Retrieved 2024-12-17.
- ^ "Investigating the Bacterial Microbiome in Brain Metastasis". The Mark Foundation for Cancer Research. 2022-06-08. Retrieved 2024-12-17.
- de Visser, Karin E.; Joyce, Johanna A. (2023-03). "The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth". Cancer Cell. 41 (3): 374–403. doi:10.1016/j.ccell.2023.02.016. ISSN 1535-6108. Archived from the original on 2023-05-07.
{{cite journal}}: Check date values in:|date=(help) - "Geoffrey Beene | Johanna Joyce, Ph.D." Retrieved 2024-12-17.
- "Award & PhD Recipients | Memorial Sloan Kettering Cancer Center". www.mskcc.org. Retrieved 2024-12-17.
- "The Fourth Annual Women in Science Lecture & Luncheon - Dominique Brustlein Bobst". www.dominique-brustlein-bobst.ch. 2015-09-01. Retrieved 2024-12-17.
- "Ludwig Cancer Research". Retrieved 2024-12-17.
- "Cloëtta Prize". Prof. Dr. Max Cloëtta Foundation. Retrieved 2024-12-17.
- "Fondation ISREC - Congratulations to Prof. Johanna Joyce !". 2021-02-04. Retrieved 2024-12-17.
- "MRS Awards And Recognitions | Metastasis Research". metastasis-research.org. Retrieved 2024-12-17.
- "Johanna Joyce: Winner of the 2023 Pezcoller-Marina Larcher Fogazzaro-EACR Women in Cancer Research Award – Agora". 2023-03-20. Retrieved 2024-12-17.
- "The Pezcoller-Marina Larcher Fogazzaro-EACR Women in Cancer Research Award | The European Association for Cancer Research". www.eacr.org. Retrieved 2024-12-17.
- "Johanna A. Joyce, PhD". American Association for Cancer Research (AACR). Retrieved 2024-12-17.
- "Prof. Johanna Joyce recognized in Cell Press's 50 Scientists that Inspire – Agora". 2024-09-11. Retrieved 2024-12-17.
- "Ludwig Cancer Research". Retrieved 2024-12-17.