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Aminoxytriphene

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Revision as of 17:55, 19 December 2024 by Mo18ekula (talk | contribs) (←Created page with '{{Infobox drug | drug_name = Aminoxytriphene | image = Aminoxytriphene.svg | width = 250px | caption = <!-- Clinical data --> | pronounce = | tradename = | Drugs.com = | MedlinePlus = | licence_CA = | licence_EU = | DailyMedID = | licence_US = | pregnancy_AU = | pregnancy_category = | dependency_liability = | addiction_liability = | routes_of_administration = | class = | ATC_prefix = | ATC_suffix = <!-- Legal status --> | legal_status =...')(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff) Pharmaceutical compound
Aminoxytriphene
Clinical data
Other namesAmotriphene, Myordil, Win 5494, Rimalcor.
Identifiers
IUPAC name
  • 2,3,3-tris(4-methoxyphenyl)-N,N-dimethylprop-2-en-1-amine
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC26H29NO3
Molar mass403.522 g·mol
3D model (JSmol)
SMILES
  • CN(C)CC(=C(C1=CC=C(C=C1)OC)C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC
InChI
  • InChI=1S/C26H29NO3/c1-27(2)18-25(19-6-12-22(28-3)13-7-19)26(20-8-14-23(29-4)15-9-20)21-10-16-24(30-5)17-11-21/h6-17H,18H2,1-5H3
  • Key:FRQGJOFRWIILCX-UHFFFAOYSA-N

Amotriphene is a coronary vasodilator that was developed at Sterling Drug is in the early 1960s. It has selective binding to alpha-adrenergic receptors.

It has a structure that is similar to Chlorotrianisene, although it is not thought to function as a non-steroidal synthetic estrogen.

Pharmacology:

References

  1. Elpern Bill, US3010965 & US3161646 (1961 & 1964 both to Sterling Drug Inc).
  2. Greenslade, Forrest C.; Newquist, Kathryn L.; Krider, Kathryn M.; Chasin, Mark; Scott, Cynthia K. (1982). "Heterogeneity of Biochemical Actions Among Vasodilators". Journal of Pharmaceutical Sciences. 71 (1): 94–100. doi:10.1002/jps.2600710123.
  3. Sandler, Gerald (1960). "Clinical evaluation of a new coronary vasodilator, 3-dimethylamino-1,1 2-tris (4-methoxyphenyl)-1-propene hydrochloride (WIN 5494)". American Heart Journal. 59 (5): 718–722. doi:10.1016/0002-8703(60)90512-3.
  4. Karczmar, A. G.; Bourgault, P.; Elpern, B. (1958). "Antiaccelerator, Coronary Dilator and Certain Other Pharmacologic Actions of New Poly-Methoxyphenyl Derivatives". Experimental Biology and Medicine. 98 (1): 114–118. doi:10.3181/00379727-98-23957.
  5. DAY HW. Angina pectoris. A clinical note in the use of Myordil (Win 5494). J Kans Med Soc. 1961 Apr;62:143. PMID: 13720339.
  6. Ruskin, Arthur (1961). "Effects of Erythrol Tetranitrate and Amotriphene on Exercise Tolerance Tests in Angina Pectoris". Circulation. 23 (5): 681–684. doi:10.1161/01.CIR.23.5.681.
  7. HARRIS R. Clinical observations of amotriphene hydrochloride. N Y State J Med. 1961 Dec 1;61:4009-14. PMID: 13904871.
Vasodilators used in cardiac diseases (C01D)
Nitrovasodilators
Quinolone vasodilators
Others
Category: