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The 1946 Murray State Thoroughbreds football team represented Murray State Teachers College (now known as Murray State University) as a member of the Kentucky Intercollegiate Athletic Conference (KIAC) during the 1946 college football season. In their second season under head coach Jim Moore, who had coached the team in 1941, the Thoroughbreds compiled an overall record of 5–5 with a mark of 2–1 in conference play tying for secon place in the KIAC.
W.J. Bingham, ed. (1947). The Official National Collegiate Athletic Association Football Guide including the Official Rules 1947. A.S. Barnes and Company. p. 113.