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Emrusolmin

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Emrusolmin
200px
Clinical data
Other namesAnle138b, TEV-56286
Legal status
Legal status
  • Investigational
Identifiers
IUPAC name
  • 5-(1,3-Benzodioxol-5-yl)-3-(3-bromophenyl)-1H-pyrazole
CAS Number
PubChem CID
DrugBank
UNII
Chemical and physical data
FormulaC16H11BrN2O2
Molar mass343.180 g·mol
3D model (JSmol)
SMILES
  • C1OC2=C(O1)C=C(C=C2)C3=CC(=NN3)C4=CC(=CC=C4)Br

Emrusolmin (development code Anle138b) is an experimental drug for the treatment of neurodegenerative diseases. It is an inhibitor of protein aggregation, particularly preventing the aggregation of α-synuclein which is implicated in the development of Parkinson's disease. Other proteins it inhibits the aggregation of include tau which is associated with Alzheimer's disease (AD) and tauopathy, and amyloid beta which is associated with AD.

It is currently in clinical trials for Parkinson's disease and multiple system atrophy.

References

  1. . doi:10.1007/s00401-013-1114-9. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  2. . doi:10.1016/j.ymeth.2023.04.002. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  3. . doi:10.1038/s41467-022-32797-w. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  4. . doi:10.1007/s00401-015-1483-3. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  5. . doi:10.15252/emmm.201707825. {{cite journal}}: Cite journal requires |journal= (help); Missing or empty |title= (help)
  6. "Emrusolmin - Modag". AdisInsight.
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