Misplaced Pages

This is an old revision of this page, as edited by Hodja Nasreddin (talk | contribs) at 03:51, 23 December 2007 (←Created page with '{{Pfam_box | Symbol = Toxin_4 | Name = Anenome neurotoxin | image = | width = | caption = | Pfam= PF00706 | InterPro= IPR000693 | SMART= | Prosite = | SCOP = 1atx |...'). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Sea anemones produce many different neurotoxins with related structure and function. Proteins belonging to this family include the neurotoxins, of which there are several, including calitoxin and anthopleurin. The neurotoxins bind specifically to the sodium channel, thereby delaying its inactivation during signal transduction, resulting in strong stimulation of mammalian cardiac muscle contraction. Calitoxin 1 has been found in neuromuscular preparations of crustaceans, where it increases transmitter release, causing firing of the axons. Three disulphide bonds are present in this protein.

References

1. Norton TR (1981). "Cardiotonic polypeptides from Anthopleura xanthogrammica (Brandt) and A. elegantissima (Brandt)". Fed. Proc. 40 (1): -. PMID 6108877.
2. Yasunobu KT, Norton TR, Reimer NS, Yasunobu CL (1985). "Amino acid sequence of the Anthopleura xanthogrammica heart stimulant, anthopleurin-B". J. Biol. Chem. 260 (15): -. PMID 4019448.{{cite journal}}: CS1 maint: multiple names: authors list (link)
3. Scanlon MJ, Pallaghy PK, Norton RS, Monks SA (1995). "Solution structure of the cardiostimulant polypeptide anthopleurin-B and comparison with anthopleurin-A". Structure. 3 (8): -. PMID 7582896.{{cite journal}}: CS1 maint: multiple names: authors list (link)

This protein-related article is a stub. You can help Misplaced Pages by expanding it.

• v
• t
• e

• Protein domains
• Toxins
• Peripheral membrane proteins
• Protein stubs