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Revision as of 20:27, 18 January 2008 by Drphilharmonic (talk | contribs) (logic, grammar, syntax)(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff)Redox signaling is the process wherein free radicals, reactive oxygen species (ROS), and other electronically-activated species act as messengers in biological systems.
History
The concept of electronically-activated species as messengers in both normal metabolism and in pathogenesis goes back to the 19th century. For example, the biological pigment melanin is a stable free radical. Charles Darwin noted that white blue-eyed cats are usually deaf and that this combination might be related to some defect in neuronal development secondary to the absence of melanin pigment. In a similar manner, it has been known for centuries that radical-generating transition-series metals such as interocular copper and iron may produce massive vitreous fibrosis (scarring) as they oxidize. We now know that reactive oxygen species likely play a key role in fibrocyte activation.
The "Adrenochrome Hypothesis" of Abram Hoffer and Humphry Osmond for the causation of schizophrenia involves the radical oxidation of the neurotransmitter epinephrine to the psychoactive compound adrenochrome.
External links
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