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When combined with additional sources of fluoride from the diet (typically from processed foods) and from dental products, cosmetic effects (dental fluorosis) have been reported, especially among children. High levels of fluoride intake have been associated with bone weakening and more controversially with bone cancer, although this evidence is considered weak. Fluoridated water alone has not been shown to cause adverse health effects in humans at the typical level of municipal water fluoridation of 1 mg/L.
- ^ Scientific American Jan. 2008 p.80 Article
- Timing of Fluoride Intake in Relation to Development of Fluorosis on Maxiallry Central Incisors. L. Hong, S. Levy at al. Community Dentistry and Oral Epidemiology Vol. 34, No. 4, pp 299-309, Aug 2006
- Age-Specific Fluoride Exposure in Drinking Water and Osteosarcoma. E. Bassin et al. Cancer Causes and Control Vol. 17, No. 4, pp 421-428, May 2006
- Caution Needed in Fluoride and Osteosarcoma Study. C. Douglas, K. Joshipura Cancer Causes and Control Vol. 17, No. 4, pp 481-482, May 2006
- CDC statement on osteosarcoma.
- CDC statement on fluoridated drinking water.