Misplaced Pages

Duloxetine

Article snapshot taken from Wikipedia with creative commons attribution-sharealike license. Give it a read and then ask your questions in the chat. We can research this topic together.

This is an old revision of this page, as edited by 76.115.41.193 (talk) at 04:58, 2 November 2008 (does not belong here. this is why people think wikipedia is shit. placed under new subheading "whiners"). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Revision as of 04:58, 2 November 2008 by 76.115.41.193 (talk) (does not belong here. this is why people think wikipedia is shit. placed under new subheading "whiners")(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff) Pharmaceutical compound
Duloxetine
Clinical data
License data
Routes of
administration
Oral
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability~ 50% (32% to 80%)
Protein binding~ 95%
MetabolismLiver, two P450 isozymes, CYP2D6 and CYP1A2.
Elimination half-life12,1 hours
Excretion70% in urine, 20% in feces
Identifiers
IUPAC name
  • (+)-(S)-N-Methyl-3-(naphthalen-1-yloxy)-
    3-(thiophen-2-yl)propan-1-amine
CAS Number
PubChem CID
DrugBank
CompTox Dashboard (EPA)
ECHA InfoCard100.116.825 Edit this at Wikidata
Chemical and physical data
FormulaC18H19NOS
Molar mass297.41456 g/mol g·mol
3D model (JSmol)
SMILES
  • CNCC(C1=CC=CS1)OC2=CC=CC3=CC=CC=C32
Cymbalta 60mg
The neutrality of this section is disputed. Relevant discussion may be found on the talk page. Please do not remove this message until conditions to do so are met. (September 2008) (Learn how and when to remove this message)

Duloxetine (brand names Cymbalta, Yentreve) is a serotonin-norepinephrine reuptake inhibitor (SNRI) used for major depressive disorder (MDD), generalized anxiety disorder (GAD), pain related to diabetic neuropathy and fibromyalgia and in some countries for stress urinary incontinence (SUI). It is manufactured and marketed by Eli Lilly.

History

Duloxetine was created by Lilly researchers. David Robertson, David Wong, a co-discoverer of fluoxetine , and Joseph Krushinski are listed as inventors on the patent application filed in 1986 and granted in 1990. The first publication on the discovery of the racemic form of duloxetine known as LY227942, was made in 1988. The (+)-enantiomer of LY227942, assigned LY248686, was chosen for further studies, because it inhibited serotonin reuptake in rat synaptosomes two times more potently than (-)-enantiomer. This molecule was subsequently named duloxetine.

Initial trials conducted in patients using regimens of 20 mg/day or less did not convincingly demonstrate its efficacy and the dose was increased to as high as 120 mg in subsequent clinical trials.

In 2001 Lilly filed a New Drug Application (NDA) for duloxetine with the US Food and Drug Administration (FDA). However, in 2003 the FDA "recommended this application as not approvable from the manufacturing and control standpoint" because of "significant cGMP violations at the finished product manufacturing facility" of Eli Lilly in Indianapolis. Additionally, "potential liver toxicity" and QTc interval prolongation appeared as a concern. The FDA experts concluded that "Duloxetine can cause hepatotoxicity in the form of transaminase elevations. It may also be a factor in causing more severe liver injury, but there are no cases in the NDA database that clearly demonstrate this. Use of duloxetine in the presence of ethanol may potentiate the deleterious effect of ethanol on the liver." The FDA also recommended "routine blood pressure monitoring" at the new highest recommended dose of 120 mg, "where 24% patients had one or more readings of 140/90 vs. 9% of placebo patients."

After the manufacturing issues were resolved, the liver toxicity warning included in the prescribing information, and the follow-up studies showed that duloxetine does not cause QTc interval prolongation, duloxetine was approved by the FDA for depression and diabetic neuropathy in 2004. In 2007 Health Canada approved duloxetine for the treatment of depression and diabetic peripheral neuropathic pain.

Duloxetine was approved for use of stress urinary incontinence (SUI) in the EU in 2004. In 2005, Lilly withdrew the duloxetine application for stress urinary incontinence (SUI) in the U.S., stating that discussions with the FDA indicated "the agency is not prepared at this time to grant approval ... based on the data package submitted." A year later Lilly abandoned the pursuit of this indication in the U.S. market.

Indications

The main uses of duloxetine are in major depressive disorder, general anxiety disorder, stress urinary incontinence, painful peripheral neuropathy and fibromyalgia. In addition, it is being studied for various other indications.


Stress urinary incontinence

Stress urinary incontinence is involuntary loss of urine when the bladder comes under strain, e.g. from coughing, sneezing or other movements that increase the intraabdominal pressure. Duloxetine was first reported to improve outcomes in SUI in 1998. Systematic reviews with meta-analysis, conducted in 2005 (Cochrane) and 2008 (University of Minnesota), each found ten controlled trials. Both systematic reviews concluded that duloxetine did not lead to cure of stress urinary incontinence in the vast majority of people, but that episodes of incontinence were reduced by about 50%. This was associated with an improvement in quality of life measurements. Mild side-effects were common, and about a fifth had to discontinue the medication because of poor tolerance.

Painful peripheral neuropathy

At 20mg per day Cymbalta showed no clinical improvement over placebo. At 60mg per day Cymbalta showed modest improvement for diabetic pain over baseline, with 51% of patients treated with Cymbalta reporting at least a 30% sustained reduction in pain. In comparison, 31% of patients treated with placebo reported this magnitude of sustained pain reduction. In one study Duloxetine treatment was considered to be safe and well tolerated with less than 20 percent discontinuation due to adverse events, another trial had a low dropout rate of 12.1 percent. Duloxetine is also used to treat nerve pain in the feet, legs, or hands due to nerve damage caused by poorly controlled diabetes. Duloxetine is thought to enhance the nerve signals within the central nervous system which naturally inhibit pain. Duloxetine is not effective for the numbness or tingling, nor is it effective for the other complications of diabetes. It does not treat the underlying nerve damage, but can help reduce the pain.

Generalized anxiety disorder

On May 11 2006, Eli Lilly and Company announced the recent submission of a supplemental New Drug Application (sNDA) to the U.S. Food and Drug Administration (FDA) for Cymbalta for the treatment of generalized anxiety disorder (GAD).

Eli Lilly said the FDA has approved Cymbalta for the treatment of GAD in February 2007. Eli Lilly said that in clinical trials patients treated with Cymbalta for GAD experienced a 46% improvement in anxiety symptoms, compared to 32% for those who took placebo, as measured by the Hamilton Anxiety Scale.

Fibromyalgia

On October 19, 2006, Eli Lilly issued a press release saying they had done trials which found that Cymbalta, at 60 mg once or twice daily, significantly reduced pain in more than half of women treated for fibromyalgia (FM), with and without major depression, according to 12-week data presented at the annual meeting of the American College of Rheumatology. Eli Lilly is in Phase III of its FM trials and is expected to submit a sNDA to the FDA for approval of Cymbalta for FM within the next 12 months.

Critics argue that randomized controlled trials of FM are difficult due to factors such as a lack of understanding of the pathophysiology and a heterogeneous FM patient population. Although there is a lack of understanding of what causes FM, it is estimated that approximately 5-7% of the U.S. population has FM, representing a large patient clientele. Eli Lilly hopes Cymbalta will be the first FDA approved medication for FM and had been promoting Cymbalta for FM since 2004.

In the study testing the efficacy of Cymbalta for FM, participants completed several questionnaires to measure the amount of pain and discomfort the disease caused them at the beginning of the study, and then at the end of each of the first two weeks and every second week for the remaining 12 weeks of the study. Researchers also tested the participants for depression.

Women who took Cymbalta had significantly less pain and discomfort than those who took the placebo. For men, who made up only 11% of the study, there was no effect from taking the medication compared with a placebo. Reportedly, depression played no part in whether or not the drug worked to control pain. The change in the level of women's pain was particularly pronounced after a month of taking the drug, then leveled off a bit before dropping again near the end of the study.

However, in one of the primary measures of pain there was no significant difference between the two groups at the end of the 12-week trial. Also, because the trial lasted only 12 weeks, it is impossible to tell how well the drug would control treatment for a longer period of time.

The Food and Drug Administration regulators approved the drug for the treatment of fibromyalgia in June 2008.

Chronic fatigue syndrome

As of January 11 2007, Eli Lilly is currently enrolling patients for double blind Phase II and Phase III trials of Cymbalta for the use of Chronic Fatigue Syndrome (CFS) in conjunction with the University of Cincinnati. CFS is characterized by severe disabling fatigue of at least six months' duration which cannot be fully explained by an identifiable medical condition. Eli Lilly has not publicly stated their hypothesis for use of Cymbalta for CFS.

Contraindications

The following contraindications are listed by the manufacturer:

  • Hypersensitivity - duloxetine is contraindicated in patients with a known hypersensitivity to duloxetine or any of the inactive ingredients.
  • MAOIs - concomitant use in patients taking MAOIs is contraindicated.
  • Uncontrolled narrow-angle glaucoma - in clinical trials, Cymbalta use was associated with an increased risk of mydriasis (dilation of the iris); therefore, its use should be avoided in patients with uncontrolled narrow-angle glaucoma, in which mydriasis can cause sudden worsening.
  • CNS acting drugs - given the primary central nervous system (CNS) effects of duloxetine, it should be used with caution when it is taken in combination with or substituted for other centrally acting drugs, including those with a similar mechanism of action.
  • Cymbalta and thioridazine should not be co-administered.

Adverse effects

This article is in list format but may read better as prose. You can help by converting this article, if appropriate. Editing help is available. (May 2008)

Nausea, somnolence, insomnia, and dizziness are the main side effects, reported by about 10% to 20% of patients.

In a trial for mild major depressive disorder (MDD), the most commonly reported treatment-emergent adverse events among duloxetine-treated patients were nausea (34.7%), dry mouth (22.7%), headache (20.0%) and dizziness (18.7%), and except for headache, these were reported significantly more often than in the placebo group:

Other side-effects include:

Duloxetine and SSRIs have been shown to cause sexual side effects in some patients, both males and females. Although usually reversible, these sexual side effects can sometimes last for months, years, or longer, even after the drug has been completely withdrawn. This disorder is known as post-SSRI sexual dysfunction.

Postmarketing spontaneous reports

Reported adverse events which were temporally correlated to Cymbalta therapy include rash, reported rarely, and the following adverse events, reported very rarely: alanine aminotransferase increased, alkaline phosphatase increased, anaphylactic reaction, angioneurotic edema, aspartate aminotransferase increased, bilirubin increased, glaucoma, hepatitis, hyponatremia, jaundice, orthostatic hypotension (especially at the initiation of treatment), Stevens-Johnson syndrome, syncope (especially at initiation of treatment), and urticaria.

A number of more serious complications, in which duloxetine may have played a role, has been published in the form of case reports:

  • The Los Angeles County Department of Coroner released a report of the first post mortem studies of duloxetine; they identified twelve cases in which duloxetine was present on toxicologic analysis, but in no case was it deemed to be the ultimate cause of death. Five cases were declared multiple drug intoxication, and two were declared suicide.
  • A case of hyponatremia induced by duloxetine was reported by doctors at Weill Cornell Medical College in New York. This is common to all SSRIs.
  • A case of dyskinesia during treatment with duloxetine was reported in Germany.
  • Two episodes of serotonin syndrome have been documented in the use of duloxetine in conjunction with other medications.
  • A case of fulminant hepatic failure involving duloxetine which resulted in death was reported by the Department of Internal Medicine, Ohio State University, Columbus, Ohio.
  • An attack of acute porphyria in a patient with known variegate porphyria who had been commenced on duloxetine.

Discontinuation syndrome

Further information: SSRI discontinuation syndrome

During marketing of other SSRIs and SNRIs, there have been spontaneous reports of adverse events occurring upon discontinuation of these drugs, particularly when abrupt, including the following: dysphoric mood, irritability, agitation, dizziness, sensory disturbances (e.g., paresthesias such as electric shock sensations), anxiety, confusion, headache, lethargy, emotional lability, insomnia, hypomania, tinnitus, and seizures. Although these events are generally self-limiting, some have been reported to be severe. This withdrawal phenomenon is known as the SSRI discontinuation syndrome. For those experiencing extreme and unusual difficulty discontinuing duloxetine, it is recommended by medical professionals that an SSRI with a longer half-life, such as fluoxetine, be administered for approximately four weeks, then discontinued, to lessen symptoms.

When discontinuing treatment with Cymbalta, the manufacturer recommends a gradual reduction in the dose, rather than abrupt cessation, whenever possible. If intolerable symptoms occur following a decrease in the dose or upon discontinuation of treatment, then resuming the previously prescribed dose may be considered. Subsequently, the physician may continue decreasing the dose but at a more gradual rate." This tapering process may be ineffective for some patients.

In MDD placebo-controlled clinical trials of up to nine weeks' duration, systematically evaluating discontinuation symptoms in patients taking duloxetine following abrupt discontinuation found the following symptoms occurring at a rate greater than or equal to 2% and at a significantly higher rate in Cymbalta-treated patients compared to those discontinuing from placebo: dizziness, nausea, headache, paresthesia, vomiting, irritability, and nightmare.

Suicidality

The FDA requires all antidepressants, including duloxetine, to carry a black box warning stating that antidepressants may increase the risk of suicide in persons younger than 25. This warning is based on statistical analyses conducted by two independent groups of the FDA experts that found a 2-fold increase of the suicidal ideation and behavior in children and adolescents, and 1.5-fold increase of suicidality in the 18–24 age group.

To obtain statistically significant results the FDA had to combine the results of 295 trials of 11 antidepressants for psychiatric indications. As suicidal ideation and behavior in clinical trials are rare, the results for any drug taken separately usually do not reach statistical significance. In line with the general results, duloxetine use in depressed adults insignificantly decreased the odds of suicidality by 12% or 20% depending of the statistical technique used. However, in the subgroup of young adults (18-24 years old) duloxetine increased the odds of suicidality 5-fold, close to statistical significance. There have been no trials of duloxetine in minors.

Several commentators noted that the data FDA used in their analysis of duloxetine-associated suicidality may have been incomplete. According to Arif Khan, the Summary Basis of Approval used by the FDA to approve duloxetine for depression contained only the mention of two completed suicides out of 3490 patients, and the rest of the data was not sufficient to "conduct any meaningful analysis." Jeanne Lenzer wrote in The Independent and Slate Magazine, and this fact was also confirmed by a Lilly spokesman, that another two completed suicides, which occurred in the depression studies ran by the Lilly's Japanese partner Shionogi, have not been reported to the FDA. According to Lenzer, four completed suicides also occurred in the trials of duloxetine for stress urinary incontinence (SUI). As these trials failed, the FDA initially insisted that any information about them is a commercial secret and cannot be released. Later, in a short statement the FDA acknowledged that in SUI trials eleven suicide attempts occurred in persons taking duloxetine vs none in the placebo group.

A series of four cases of duloxetine-associated suicidality has been reported. In all four cases depressed patients began having suicidal thoughts after starting on duloxetine or increasing its dose. These thoughts stopped, and the patients returned to normal after duloxetine was discontinued, and they were switched to another antidepressant.

A suicide of 19-year-old Traci Johnson, a healthy volunteer in a duloxetine clinical pharmacology study, was highly publicized. For about a month she had been given high doses of duloxetine, and then she was switched to placebo. Four days after the switch, she hanged herself with her scarf from a shower rod in the bathroom of Lilly Laboratory for Clinical Research. The New York Times article mentioned a withdrawal syndrome as a possible reason for this suicide.

Pharmacology

A study by Bymaster and colleagues found that duloxetine inhibited binding to the human norepinephrine (NE) and serotonin (5-HT) transporters.

See also

References

  1. "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
  2. Robertson DW, Wong DT, Krushinski JH (1990-09-11). "United States Patent 4,956,388: 3-Aryloxy-3-substituted propanamines" (htm). USPTO. Retrieved 2008-05-17.{{cite web}}: CS1 maint: multiple names: authors list (link)
  3. Wong DT, Robertson DW, Bymaster FP, Krushinski JH, Reid LR (1988). "LY227942, an inhibitor of serotonin and norepinephrine uptake: biochemical pharmacology of a potential antidepressant drug". Life Sci. 43 (24): 2049–57. doi:10.1016/0024-3205(88)90579-6. PMID 2850421.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  4. Bymaster FP, Beedle EE, Findlay J; et al. (2003). "Duloxetine (Cymbalta), a dual inhibitor of serotonin and norepinephrine reuptake". Bioorg. Med. Chem. Lett. 13 (24): 4477–80. PMID 14643350. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  5. Turcotte JE, Debonnel G, de Montigny C, Hébert C, Blier P (2001). "Assessment of the serotonin and norepinephrine reuptake blocking properties of duloxetine in healthy subjects". Neuropsychopharmacology. 24 (5): 511–21. doi:10.1016/S0893-133X(00)00220-7. PMID 11282251. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  6. For example, see: Goldstein DJ, Mallinckrodt C, Lu Y, Demitrack MA (2002). "Duloxetine in the treatment a double-blind clinical trial". J Clin Psychiatry. 63 (3): 225–31. PMID 11926722. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  7. "Approval package for: application number NDA 721-427. Administrative/Correspondence #2" (PDF). The FDA Center for Drug Evaluation and Research. 2003. Retrieved 2008-05-18.
  8. FDA news
  9. Health Canada Notice of Compliance Database - duloxetine. November 1, 2007, retrieved November 24, 2007.
  10. Steyer R (2006-02-15). "Lilly Won't Pursue Yentreve for U.S." (htm). TheStreet.com. Retrieved 2008-05-18.
  11. Voelker R (1998). "International group seeks to dispel incontinence "taboo"". JAMA. 280 (11): 951–3. PMID 9749464. {{cite journal}}: Unknown parameter |month= ignored (help)
  12. Mariappan P, Ballantyne Z, N'Dow JM, Alhasso AA (2005). "Serotonin and noradrenaline reuptake inhibitors (SNRI) for stress urinary incontinence in adults". Cochrane Database Syst Rev (3): CD004742. doi:10.1002/14651858.CD004742.pub2. PMID 16034945.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  13. Shamliyan TA, Kane RL, Wyman J, Wilt TJ (2008). "Systematic review: randomized, controlled trials of nonsurgical treatments for urinary incontinence in women". Ann. Intern. Med. 148 (6): 459–73. PMID 18268288. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  14. Goldstein DJ, Lu Y, Detke MJ, Lee TC, Iyengar S (2005). "Duloxetine vs. placebo in patients with painful diabetic neuropathy". Pain. 116 (1–2): 109–18. doi:10.1016/j.pain.2005.03.029. PMID 15927394. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  15. Raskin J, Pritchett YL, Wang F; et al. (2005). "A double-blind, randomized multicenter trial comparing duloxetine with placebo in the management of diabetic peripheral neuropathic pain". Pain Med. 6 (5): 346–56. doi:10.1111/j.1526-4637.2005.00061.x. PMID 16266355. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  16. Essential Science Indicators
  17. News-Medical.Net February 26, 2007
  18. National Fibromyalgia Association Brochure
  19. ^ Arnold LM, Lu Y, Crofford LJ; et al. (2004). "A double-blind, multicenter trial comparing duloxetine with placebo in the treatment of fibromyalgia patients with or without major depressive disorder". Arthritis Rheum. 50 (9): 2974–84. doi:10.1002/art.20485. PMID 15457467. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  20. "FDA Approves Cymbalta® for the Management of Fibromyalgia". Eli Lilly Co. 2008-06-16. Retrieved 2008-06-17.
  21. Clinicaltrials.gov
  22. Cymbalta package insert. Indianapolis, IN: Eli Lilly Pharmaceuticals; 2004, September.
  23. Perahia DG, Kajdasz DK, Walker DJ, Raskin J, Tylee A (2006). "Duloxetine 60 mg once daily in the treatment of milder major depressive disorder". Int. J. Clin. Pract. 60 (5): 613–20. doi:10.1111/j.1368-5031.2006.00956.x. PMID 16700869. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link) PMC 1473178
  24. Cymbalta Side Effects, and Drug Interactions - RxList Monographs
  25. Anderson D, Reed S, Lintemoot J; et al. (2006). "A first look at duloxetine (Cymbalta) in a postmortem laboratory". J Anal Toxicol. 30 (8): 576–80. PMID 17132255. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  26. Safdieh JE, Rudominer R (2006). "A case of hyponatremia induced by duloxetine". J Clin Psychopharmacol. 26 (6): 675–6. doi:10.1097/01.jcp.0000246207.73034.96. PMID 17110834. {{cite journal}}: Unknown parameter |month= ignored (help)
  27. Deuschle M, Mase E, Zink M (2006). "Dyskinesia during treatment with duloxetine". Pharmacopsychiatry. 39 (6): 237–8. doi:10.1055/s-2006-951608. PMID 17124651. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  28. Strouse TB, Kerrihard TN, Forscher CA, Zakowski P (2006). "Serotonin syndrome precipitated by linezolid in a medically ill patient on duloxetine". J Clin Psychopharmacol. 26 (6): 681–3. doi:10.1097/01.jcp.0000239793.29449.75. PMID 17110838. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  29. Keegan MT, Brown DR, Rabinstein AA (2006). "Serotonin syndrome from the interaction of cyclobenzaprine with other serotoninergic drugs". Anesth. Analg. 103 (6): 1466–8. doi:10.1213/01.ane.0000247699.81580.eb. PMID 17122225. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  30. Hanje AJ, Pell LJ, Votolato NA, Frankel WL, Kirkpatrick RB (2006). "Case report: fulminant hepatic failure involving duloxetine hydrochloride". Clin. Gastroenterol. Hepatol. 4 (7): 912–7. doi:10.1016/j.cgh.2006.04.018. PMID 16797245. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  31. Loper T, Touchet B (2007). "An acute attack of porphyria in a patient taking duloxetine". Psychosomatics. 48 (2): 179–80. doi:10.1176/appi.psy.48.2.179. PMID 17329617.
  32. Cymbalta patient information sheet. Indianapolis, IN: Eli Lilly Pharmaceuticals; July 2006
  33. Perahia DG, Kajdasz DK, Desaiah D, Haddad PM (2005). "Symptoms following abrupt discontinuation of duloxetine treatment in patients with major depressive disorder". J Affect Disord. 89 (1–3): 207–12. doi:10.1016/j.jad.2005.09.003. PMID 16266753. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  34. Levenson M, Holland C. "Antidepressants and Suicidality in Adults: Statistical Evaluation. (Presentation at Psychopharmacologic Drugs Advisory Committee; December 13, 2006)". Retrieved 2007-05-13.
  35. ^ Stone MB, Jones ML (2006-11-17). "CLINICAL REVIEW: RELATIONSHIP BETWEEN ANTIDEPRESSANT DRUGS AND SUICIDALITY IN ADULTS" (PDF). Overview for December 13 Meeting of Psychopharmacologic Drugs Advisory Committee (PDAC). FDA. pp. 11–74. Retrieved 2007-09-22. {{cite web}}: Cite has empty unknown parameter: |coauthors= (help)
  36. ^ Levenson M, Holland C (2006-11-17). "Statistical Evaluation of Suicidality in Adults Treated with Antidepressants" (PDF). Overview for December 13 Meeting of Psychopharmacologic Drugs Advisory Committee (PDAC). FDA. pp. 75–140. Retrieved 2007-09-22. {{cite web}}: Cite has empty unknown parameter: |coauthors= (help)
  37. Khan A, Schwartz K (2007). "Suicide risk and symptom reduction in patients assigned to placebo in duloxetine and escitalopram clinical trials: analysis of the FDA summary basis of approval reports". Ann Clin Psychiatry. 19 (1): 31–6. doi:10.1080/10401230601163550. PMID 17453659.
  38. Jeanne Lenzer (2005-09-27). "What the FDA isn't telling" (html). Slate Magazine. Retrieved 2008-01-20. {{cite web}}: Cite has empty unknown parameter: |coauthors= (help)
  39. ^ Jeanne Lenzer and Nicholas Pyke (2005-06-05). "Was Traci Johnson driven to suicide by anti-depressants? That's a trade secret, say US officials" (html). Independent Online Edition. Retrieved 2008-01-20. {{cite web}}: Cite has empty unknown parameter: |coauthors= (help)
  40. "Historical Information on Duloxetine hydrochloride (marketed as Cymbalta)" (html). FDA. 2005-06. Retrieved 2008-01-20. {{cite web}}: Check date values in: |date= (help); Cite has empty unknown parameter: |coauthors= (help)
  41. Parikh AR; Thatcher BT; Tamano EA; Liskow BI (2008). "Suicidal Ideation Associated With Duloxetine Use: A Case Series". J Clin Psychopharmacolgy. 28 (1): 102.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  42. Walter F. Naedele (2004-02-12). "Drug test altered in wake of suicide" (html). Philadelphia Inquirer. Retrieved 2008-01-20. {{cite web}}: Cite has empty unknown parameter: |coauthors= (help)
  43. ^ Gardiner Harris (2004-02-12). "Student, 19, in Trial of New Antidepressant Commits Suicide" (html). New York Times. Retrieved 2008-01-20. {{cite web}}: Cite has empty unknown parameter: |coauthors= (help)
  44. Bymaster FP, Dreshfield-Ahmad LJ, Threlkeld PG, Shaw JL, Thompson L, Nelson DL, Hemrick-Luecke SK, Wong DT. "Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors". Neuropsychopharmacology. 2001 Dec;25(6):871-80

External links

Antidepressants (N06A)
Specific reuptake inhibitors and/or receptor modulators
SSRIsTooltip Selective serotonin reuptake inhibitors
SNRIsTooltip Serotonin–norepinephrine reuptake inhibitors
NRIsTooltip Norepinephrine reuptake inhibitors
NDRIsTooltip Norepinephrine–dopamine reuptake inhibitors
NaSSAsTooltip Noradrenergic and specific serotonergic antidepressants
SARIsTooltip Serotonin antagonist and reuptake inhibitors
SMSTooltip Serotonin modulator and stimulators
Others
Tricyclic and tetracyclic antidepressants
TCAsTooltip Tricyclic antidepressants
TeCAsTooltip Tetracyclic antidepressants
Others
Monoamine oxidase inhibitors
Non-selective
MAOATooltip Monoamine oxidase A-selective
MAOBTooltip Monoamine oxidase B-selective
Adjunctive therapies
Miscellaneous
Categories: