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A dimer is a chemical or biological entity consisting of two structurally similar subunits called monomers, which are held together by either intramolecular forces (covalent bonds) or weaker intermolecular forces.

Chemistry

An example of a molecular dimer (i.e. held together by intramolecular forces) is dicyclopentadiene, wherein two cyclopentadiene molecules have reacted to give the product.

Molecular dimers are often formed by the reaction of two identical compounds e.g.: 2A → A-A.

In this example, monomer "A" is said to dimerise to give the dimer "A-A". Diaminocarbenes are another example which dimerise, to give tetraaminoethylenes.

An example of an intermolecular or physical dimer is acetic acid wherein hydrogen bonds hold the two molecules together. The water dimer is another such dimer.

The term homodimer is used when the two molecules are identical (e.g. A-A) and heterodimer when they are not (e.g. A-B).

The reverse of dimerisation is often called dissociation.

Biochemistry

In biochemistry and molecular biology, dimers of macromolecules like proteins and nucleic acids are often observed. The dimerization of identical subunits is called homodimerization; the dimerization of different subunits or unrelated monomers is called heterodimerization. Most dimers in biochemistry are not connected by covalent bonds with the exception of disulfide bridges. An example of this would be the enzyme reverse transcriptase, which is made of two different amino acid chains.

Examples

• Nucleic acids:
  • DNA
• DNA Polymerase
• Proteins:
  • Antibodies
  • Protein kinases:
    • Receptor tyrosine kinases
  • Transcription factors
    • Leucine zipper motif proteins
    • Nuclear receptors
  • 14-3-3 proteins
  • G protein-coupled receptors
  • G protein βγ-subunit dimer
  • Kinesin
  • Triosephosphateisomerase (TIM)
  • Alcohol dehydrogenase
  • Factor XI
  • Factor XIII
  • Toll-like receptor
  • Fibrinogen

See also

• Monomer
• Trimer
• Heteromer
• Oligomer
• Polymer
• Dimer model

References

External links

• Reverse transcriptase
• Homo and hetero dimeric proteins

• Articles lacking sources from August 2006
• Chemical compounds