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Tricyclic antidepressants are a class of antidepressant drugs

first used in the 1960s.

Although they remain effective, they have been increasingly replaced by

SSRIs because the difference between

a therapeutic and a toxic dose of a tricyclic antidepressant is small. Like monoamine oxidase inhibitors, this posed a

difficulty for the physician in that they were prescribing a

medication for a depressed person that could be used to

commit suicide.