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Tacalcitol

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Tacalcitol
Clinical data
Other names(1R,3S,5Z)-5--7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
Routes of
administration		Topical
ATC code
Identifiers
IUPAC name
  • (1S,3R,5Z,7E,24R)-9,10-secocholesta-5,7,10-triene-1,3,24-triol
CAS Number
PubChem CID
CompTox Dashboard (EPA)
ECHA InfoCard100.220.855 Edit this at Wikidata
Chemical and physical data
FormulaC27H44O3
Molar mass416.64 g·mol

Tacalcitol is a synthetic vitamin D3 analogue.

Tacalcitol is marketed under several names, including Curatoderm and Bonalfa.

Mechanism

Tacalcitol exerts its biological activity by preventing the proliferation of keratinocytes.

Uses

It is used to treat psoriasis.

It has been used for vitiligo and Hailey-Hailey disease.

References

  1. Fukuoka M, Sakurai K, Ohta T, Kiyoki M, Katayama I (2001). "Tacalcitol, an active vitamin D3, induces nerve growth factor production in human epidermal keratinocytes". Skin Pharmacol. Appl. Skin Physiol. 14 (4): 226–33. PMID 11464105.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. Leone G, Pacifico A, Iacovelli P, Paro Vidolin A, Picardo M (2006). "Tacalcitol and narrow-band phototherapy in patients with vitiligo". Clin. Exp. Dermatol. 31 (2): 200–5. doi:10.1111/j.1365-2230.2005.02037.x. PMID 16487090. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  3. Aoki T, Hashimoto H, Koseki S, Hozumi Y, Kondo S (1998). "1alpha,24-dihydroxyvitamin D3 (tacalcitol) is effective against Hailey-Hailey disease both in vivo and in vitro". Br. J. Dermatol. 139 (5): 897–901. doi:10.1046/j.1365-2133.1998.02522.x. PMID 9892963. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
Drugs used for psoriasis (D05)
Topical
Tars
Antracens
Psoralens
Other
Systemic
Psoralens
Retinoids


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