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Polidocanol

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Revision as of 18:05, 25 February 2011 by CheMoBot (talk | contribs) (Updating {{drugbox}} (changes to watched fields - updated 'UNII_Ref', 'StdInChI_Ref', 'StdInChIKey_Ref', 'ChEMBL_Ref') per Chem/Drugbox validation (report [[Misplaced Pages talk:WikiProject_Pharmacolog)(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff) Pharmaceutical compound
Polidocanol
Clinical data
Other names 
  • Polydocanol
  • Laureth 9
  • Macrogol lauryl ether
  • Lauromacrogol
  • PEG-9 lauryl alcohol
  • POE-9 lauryl alcohol
  • Dodecylpolyethyleneglycolether
  • Hydroxyl polyethoxy dodecane
  • Oxypolyethoxydodecane
Pregnancy
category
  • Topical: allowed
    Injection: contraindication in months 1–3 and after week 36
ATC code
Legal status
Legal status
  • OTC (topical), ℞ (injection)
Identifiers
CAS Number
PubChem CID
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.019.351 Edit this at Wikidata
Chemical and physical data
FormulaC30H62O10
Molar mass~600 g/mol (average) g·mol
  (verify)

Polidocanol is a local anaesthetic and antipruritic component of ointments and bath additives. It relieves itching caused for example by dry skin conditions such as eczema.

The substance is also used as a sclerosant, an irritant injected to treat varicose veins, under the trade names Asclera and Aethoxysklerol. Polidocanol causes fibrosis inside varicose veins, occluding the lumen of the vessel, and reducing the appearance of the varicosity.

The FDA has approved polidocanol injections for the treatment of small varicose (less than 1 mm in diameter) and reticular veins (1 to 3 mm in diameter). Polidocanol works by damaging the cell lining of blood vessels, causing them to close and eventually be replaced by other types of tissue.

Pure polidocanol for pharmaceutical use

References

  1. "E45 itch relief cream". netdoctor.co.uk. Retrieved 2007-07-12.
  2. Sclerotherapy, Laurence Z Rosenberg, MD, eMedicine.com
  3. Facts and Companies: Varicose Vein Treatment Approved
  4. "Asclera Full Prescribing Information in Drug Reference Encyclopedia". Retrieved 2010-04-11.
Vasoprotectives (C05)
Antihemorrhoidals for topical use
corticosteroids
local anesthetics
other
Antivaricose therapy
heparins or heparinoids for topical use
sclerosing agents for local injection
other
Capillary stabilising agents
bioflavonoids
other


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