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Simeticone

Clinical data
Routes of administration	Oral
ATC code	A03AX13 (WHO)
Legal status
Legal status	US: OTC
Pharmacokinetic data
Bioavailability	not absorbed from the gut
Protein binding	N/A
Metabolism	N/A
Elimination half-life	N/A
Excretion	N/A
Identifiers
IUPAC name Poly(dimethylsiloxane), silicon dioxide
CAS Number	8050-81-5
PubChem CID	6433516
CompTox Dashboard (EPA)	DTXSID00904918
ECHA InfoCard	100.107.016
Chemical and physical data
Formula	(C2H6OSi)n · (SiO2)m
Molar mass	variable
(verify)

Simethicone is an oral anti-foaming agent used to reduce bloating, discomfort and pain caused by excess gas in the stomach or intestinal tract. It is a mixture of polydimethylsiloxane and silica gel.

Chemical action and pharmaceutical effects

Simethicone is an anti-foaming agent that decreases the surface tension of gas bubbles, causing them to combine into larger bubbles in the stomach that can be passed more easily by burping. Simethicone does not reduce or prevent the formation of gas in the digestive tract, rather, it increases the rate at which it exits the body. However, simethicone can relieve pain caused by gas in the intestines by decreasing foaming which then allows for passing of flatus. Simethicone is not absorbed by the body into the bloodstream, and is therefore considered relatively safe, with sources reporting the worst side effects as bloating, constipation, diarrhea, gas and heartburn. While sold as a treatment for colic, randomised controlled trials have not borne this claim out.

Simethicone solutions of differing concentration also have industrial applications for reducing foaming in certain chemical processes.

Dosage

Simethicone comes in many different oral forms, which have differing usual dosages. Though there are standard dosages for adults and teens, dosages for children should be determined by a doctor.

• Capsules or tablets:

Adults and teenagers: 60 to 125 milligrams (mg) four times a day, or 180mg twice a day, after meals and at bedtime. No more than 500 mg should be taken in twenty-four hours.

• Chewable tablets:

Adults and teenagers: 40 to 125 mg four times a day, after meals and at bedtime or the dose may be 150 mg three times a day, after meals. No more than 500 mg should be taken in twenty-four hours.

• Suspension:

Adults and teenagers: 40 to 95 mg four times a day, after meals and at bedtime. No more than 500 mg should be taken in twenty-four hours.

• Dissolving membrane:

A thin dissolving membrane dose that is placed on the tongue and dissolves with saliva. No more than 500 mg should be taken in twenty-four hours.

Availability

Simethicone is generally available over the counter under many trade names in varying dosage sizes and combinations with other drugs, including:

Other uses

Simethicone is used in some detergents when foaming is unwanted.

Simethicone is also used in the fermentation process to reduce the shearing of proteins by agitation.

References

1. Norton, William (2005-01-09). "Controlling Intestinal Gas". Retrieved 2007-07-31.
2. University of Michigan clinical trial for simethicone used for colic
3. Patient.co.uk on colic
4. Product information Template:De icon
5. Product information Template:De icon

External links

• "Jackson Gastroenterology - Patient Education - Simethicone". Retrieved July 30, 2005.
• "Medline Plus - Simethicone". Archived from the original on February 19, 2007. Retrieved April 16, 2007.

• Antiflatulents
• Food additives
• Organosilicon polymers
• Silicon dioxide
• Silicones