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R-30490

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This is an old revision of this page, as edited by CheMoBot (talk | contribs) at 02:35, 12 July 2011 (Updating {{drugbox}} (no changed fields - added verified revid - updated 'UNII_Ref', 'ChemSpiderID_Ref', 'StdInChI_Ref', 'StdInChIKey_Ref', 'ChEMBL_Ref', 'KEGG_Ref') per Chem/Drugbox validation (). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Revision as of 02:35, 12 July 2011 by CheMoBot (talk | contribs) (Updating {{drugbox}} (no changed fields - added verified revid - updated 'UNII_Ref', 'ChemSpiderID_Ref', 'StdInChI_Ref', 'StdInChIKey_Ref', 'ChEMBL_Ref', 'KEGG_Ref') per Chem/Drugbox validation ()(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff) Pharmaceutical compound
R-30490
Clinical data
Pregnancy
category
  • ?
Pharmacokinetic data
Bioavailability?
Protein binding?
Metabolism?
Excretion?
Identifiers
IUPAC name
  • N--N-phenyl-propanamide
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC24H32N2O2
Molar mass380.522 g/mol g·mol
3D model (JSmol)
SMILES
  • c2ccccc2N(C(=O)CC)C1(COC)CCN(CC1)CCc3ccccc3
  (verify)

R-30490 is an opioid analgesic drug related to the highly potent animal tranquilizer carfentanil, and with only slightly lower potency. It was first synthesised by a team of chemists at Janssen Pharmaceutica led by Paul Janssen, who were investigating the structure-activity relationships of the fentanyl family of drugs. R-30490 was found to be the most selective agonist for the mu opioid receptor out of all the fentanyl analogues tested, but it has never been introduced for medical use in humans, although the closely related drug sufentanil is widely used for analgesia and anesthesia during major surgery.


References

  1. Cometta-Morini C, Maguire PA, Loew GH (1992). "Molecular determinants of mu receptor recognition for the fentanyl class of compounds". Molecular Pharmacology. 41 (1): 185–96. PMID 1310142. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
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