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Tocofersolan

Names
IUPAC name α--2H-1-benzopyran-6-yl]oxy]-1,4-dioxobutyl]-ω-hydroxy-poly(oxy-1,2-ethanediyl)
Other names Tocofersolan; Vitamin E PEG succinate; α-Tocopherol polyethylene glycol succinate; Liqui-E
Identifiers
CAS Number	9002-96-4
3D model (JSmol)	Interactive image
ChemSpider	64498
ECHA InfoCard	100.123.651
PubChem CID	9938056
CompTox Dashboard (EPA)	DTXSID90872278 DTXSID1048623, DTXSID90872278
InChI InChI=1S/C35H58O6/c1-24(2)12-9-13-25(3)14-10-15-26(4)16-11-20-35(8)21-19-30-29(7)33(27(5)28(6)34(30)41-35)40-32(38)18-17-31(37)39-23-22-36/h24-26,36H,9-23H2,1-8H3Key: AOBORMOPSGHCAX-UHFFFAOYSA-N InChI=1/C35H58O6/c1-24(2)12-9-13-25(3)14-10-15-26(4)16-11-20-35(8)21-19-30-29(7)33(27(5)28(6)34(30)41-35)40-32(38)18-17-31(37)39-23-22-36/h24-26,36H,9-23H2,1-8H3Key: AOBORMOPSGHCAX-UHFFFAOYAU
SMILES O=C(OCCO)CCC(=O)Oc2c(c(c1OC(CCc1c2C)(C)CCCC(C)CCCC(C)CCCC(C)C)C)C
Properties
Chemical formula	(C2H4O)nC33H54O5
Molar mass	Variable
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Y verify (what is  ?) Infobox references

Tocofersolan (INN) or tocophersolan is a synthetic water-soluble version of vitamin E. Natural forms of vitamin E are fat soluble, but not water-soluble. Tocofersolan is polyethylene glycol derivative of α-tocopherol that enables water solubility.

Tocofersolan is used as a vitamin E supplement or to treat vitamin E deficiency in individuals who cannot absorb fats due to disease. On the 24th July 2009 the European Medicines Agency approved tocofersolan under the trade name Vedrop 50 mg/ml oral solution for the treatment of vitamin E deficiency due to digestive malabsorption in paediatric patients suffering from congenital or hereditary chronic cholestasis, from birth (in term newborns) to 16 or 18 years of age (depending on the region).

Tocofersolan is also used in cosmetics and pharmaceuticals as an antioxidant.

References

1. "Tocophersolan Oral". WebMD.
2. "Vedrop Summary of Product Characteristics" (PDF). European Medicines Agency.
3. Ash, Michael; Ash, Irene. Handbook of Preservatives. p. 568. ISBN 1890595667.

• Vitamins