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Ganirelix

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Revision as of 22:26, 31 August 2011 by BogBot (talk | contribs) (populated new fields in {{drugbox}} and reordered per bot approval. Report errors and suggestions to User_talk:BogBot)(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff) Pharmaceutical compound
Ganirelix
Clinical data
AHFS/Drugs.comMonograph
Routes of
administration		Subcutaneous injection
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability91.1%
Protein binding81.9%
Elimination half-life12.8 hours
ExcretionFaecal / Renal (approx. 75%/22%)
Identifiers
IUPAC name
  • (2S)-1-amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-6-hexanoyl]amino]-4-methylpentanoyl]amino]-6-hexanoyl]-N-pyrrolidine-2-carboxamide
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.216.077 Edit this at Wikidata
Chemical and physical data
FormulaC80H113ClN18O13
Molar mass1570.4 g/mol g·mol
InChI
  • InChI=1S/C80H113ClN18O13/c1-9-84-79(85-10-2)88-39-17-15-27-60(70(104)94-62(42-49(5)6)71(105)93-61(28-16-18-40-89-80(86-11-3)87-12-4)78(112)99-41-21-29-68(99)77(111)90-50(7)69(82)103)92-72(106)63(44-53-32-36-58(102)37-33-53)97-76(110)67(48-100)98-74(108)65(45-54-22-20-38-83-47-54)96-73(107)64(43-52-30-34-57(81)35-31-52)95-75(109)66(91-51(8)101)46-56-25-19-24-55-23-13-14-26-59(55)56/h13-14,19-20,22-26,30-38,47,49-50,60-68,100,102H,9-12,15-18,21,27-29,39-46,48H2,1-8H3,(H2,82,103)(H,90,111)(H,91,101)(H,92,106)(H,93,105)(H,94,104)(H,95,109)(H,96,107)(H,97,110)(H,98,108)(H2,84,85,88)(H2,86,87,89)/t50-,60-,61+,62+,63+,64-,65-,66-,67+,68+/m1/s1
  • Key:BJQRBVMMHKUPPY-YYXZGPOZSA-N

Ganirelix acetate (or diacetate) is an injectable gonadotropin-releasing hormone antagonist (GnRH antagonist). It is primarily used in assisted reproduction to control ovulation. The drug works by blocking the action of GnRH upon the pituitary, thus rapidly suppressing the production and action of LH and FSH. It is administered as a daily subcutaneous injection.

Ganirelix is marketed by Organon International as Antagon.

GnRHTooltip Gonadotropin-releasing hormone and gonadotropins
GnRH modulators
(incl. analogues)
Agonists
Antagonists
Gonadotropins
Preparations
Others
(indirect)
Progonadotropins
Antigonadotropins
See also
GnRH and gonadotropin receptor modulators
Androgens and antiandrogens
Estrogens and antiestrogens
Progestogens and antiprogestogens
Hypothalamic-pituitary hormones and analogues (H01)
Hypothalamus
Gonadotropin-releasing hormone (GnRH)
Somatostatin
Anterior pituitary
Adrenocorticotropic hormone (ACTH)
Growth hormone (GH)

Antagonists: Pegvisomant

Thyroid-stimulating hormone (TSH)
Posterior pituitary
Oxytocin
Vasopressin
Categories: