Licochalcone A - Misplaced Pages

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Licochalcone A
Names

IUPAC name (E)-3--1-(4-hydroxyphenyl)prop-2-en-1-one
Other names Licochalcone a
Identifiers
CAS Number	58749-22-7
3D model (JSmol)	Interactive image
ECHA InfoCard	100.163.544
PubChem CID	5318998
CompTox Dashboard (EPA)	DTXSID10904181
SMILES CC(C)(C=C)C1=C(C=C(C(=C1)C=CC(=O)C2=CC=C(C=C2)O)OC)O
Properties
Chemical formula	C₂₁H₂₂O₄
Molar mass	338.39 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Y verify (what is ?) Infobox references

Chemical compound

Licochalcone A is a chalconoid, a type of natural phenols. It can be isolated from root of Glycyrrhiza glabra or Glycyrrhiza inflata. It shows antimalarial properties in vitro.

References

Licochalcone-A, a novel flavonoid isolated from licorice root (Glycyrrhiza glabra), causes G2 and late-G1 arrests in androgen-independent PC-3 prostate cancer cells. Yue Fu, Tze-chen Hsieh, Junqiao Guo, Jan Kunicki, Marietta Y.W.T. Lee, Zbigniew Darzynkiewicz and Joseph M. Wu, Biochemical and Biophysical Research Communications, Volume 322, Issue 1, 10 September 2004, pp. 263-270, doi:10.1016/j.bbrc.2004.07.094
In Vitro Antimycobacterial and Antilegionella Activity of Licochalcone A from Chinese Licorice Roots. Alice Friis-Møller, Ming Chen, Kurt Fuursted, Søren Brøgger Christensen and Arsalan Kharazmi, Planta Med 2002, 68(5), pp. 416-419, doi:10.1055/s-2002-32087
Licochalcone A, a new antimalarial agent, inhibits in vitro growth of the human malaria parasite Plasmodium falciparum and protects mice from P. yoelii infection. M Chen, T G Theander, S B Christensen, L Hviid, L Zhai and A Kharazmi, Antimicrob Agents Chemother, 1994 July, 38(7), pp. 1470–1475, PMC PMC284578

v t e Chalconoids and their glycosides
Chalconoids	Butein Isoliquiritigenin Methyl hydroxychalcone Okanin
Chalconoid glycosides	Carthamin Marein okanin 3,4,3′-trimethyl ether 4′-glucoside okanin 4-methyl ether 4′-glucoside okanin 4-methyl ether 4′-glucoside monoacetate Okanin 3,4-dimethyl ether 4′-glucoside
Acylated chalconoids	Licochalcone A Sophoradin (prenylated) Tephrospinosin (3′,5′-diisopentenyl-2′,4′-dihydroxychalcone) (prenylated) Xanthohumol (prenylated)
O-methylated chalconoids	Cardamomin Flavokawin B Okanin 3,4,3′,4′-tetramethyl ether Pashanone (2',6'-Dihydroxy-3',4'-dimethoxychalcone)
Flavokavains	Flavokavain A Flavokavain B Flavokavain C
Synthetic	Sofalcone

Template:Natural-phenol-stub

Category:

Chalconoids