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Mannose 6-phosphate

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Mannose 6-phosphate
Identifiers
CAS Number
3D model (JSmol)
ChEBI
ChemSpider
MeSH mannose-6-phosphate
PubChem CID
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C6H13O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6?/m1/s1Key: NBSCHQHZLSJFNQ-QTVWNMPRSA-N
SMILES
  • O=P(O)(O)OC1OC(O)(O)(O)1O
Properties
Chemical formula C6H13O9P
Molar mass 260.136 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). checkY verify (what is  ?) Infobox references
Chemical compound

Mannose-6-phosphate (M6P) is a molecule bound by lectin in the immune system. M6P is converted to fructose 6-phosphate by mannose phosphate isomerase.

M6P is a targeting signal for acid hydrolase precursor proteins that are destined for transport to lysosomes. The M6P tag is added to such proteins in the cis-Golgi apparatus. Specifically, in a reaction involving uridine diphosphate (UDP) and N-acetylglucosamine, the enzyme UDP-N-acetylglucosamine:N-acetylglucosaminyl-1-phosphotransferase catalyzes the N-linked glycosylation of asparagine residues with M6P. Once appropriately marked with the M6P targeting signal, these proteins are moved to the trans-Golgi. There, the M6P moiety is recognized by mannose 6-phosphate receptor (MPR) proteins.

The MPRs traffic in vesicles to the lysosome via an endosome.

See also

External links


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Fructose and galactose metabolic intermediates
Fructose
Galactose
Mannose
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