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UK-414,495

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Revision as of 20:12, 20 September 2011 by CheMoBot (talk | contribs) (Updating {{drugbox}} (no changed fields - added verified revid - updated 'ChemSpiderID_Ref', 'UNII_Ref', 'ChEMBL_Ref', 'ChEBI_Ref', 'KEGG_Ref', 'StdInChI_Ref', 'StdInChIKey_Ref', 'ChEBI_Ref') per Chem/Drugbox validation (report [[Wik)(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff) Pharmaceutical compound
UK-414,495
Identifiers
IUPAC name
  • (R)-2-({1-cyclopentyl}methyl)valeric acid
CAS Number
PubChem CID
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC16H25N3O3S
Molar mass339.452 g/mol g·mol
3D model (JSmol)
SMILES
  • CCc1nnc(s1)NC(=O)C2(CC(C(O)=O)CCC)CCCC2
  (verify)

UK-414,495 is a drug developed by Pfizer for the treatment of female sexual arousal disorder. UK-414,495 acts as a potent, selective inhibitor of the enzyme neutral endopeptidase, which normally serves to break down the neuropeptide VIP. The consequent increase in VIP activity alters blood flow to the genital region leading to increased lubrication and muscle relaxation.

See also

References

  1. 'Female Viagra' will help women increase their sexual arousal. Daily Mail Online 14th April 2010
  2. Armer R, Warne P, Witherington J (2006). "Recent disclosures of clinical drug candidates". Drug News & Perspectives. 19 (1): 65–72. PMID 16550257.{{cite journal}}: CS1 maint: multiple names: authors list (link) ISSN 0214-0934
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