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Gallamine triethiodide

Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	M03AC02 (WHO)
Identifiers
IUPAC name 2,2’,2’’-tris(N,N,N-triethylethanaminium) triiodide
CAS Number	65-29-2
PubChem CID	6172
IUPHAR/BPS	356
DrugBank	APRD00712
ChemSpider	5937
UNII	Q3254X40X2
KEGG	D02292
ChEBI	CHEBI:503442
ChEMBL	ChEMBL1200993
Chemical and physical data
Formula	C30H60N3O3 · 3 I (gallamine triethiodide) C24H45N3O3 (gallamine)
Molar mass	891.529 g/mol (gallamine triethiodide) 423.633 g/mol (gallamine)
3D model (JSmol)	Interactive image
SMILES ...O(c1c(OCC(CC)(CC)CC)cccc1OCC(CC)(CC)CC)CC(CC)(CC)CC
InChI InChI=1S/C24H45N3O3/c1-7-25(8-2)16-19-28-22-14-13-15-23(29-20-17-26(9-3)10-4)24(22)30-21-18-27(11-5)12-6/h13-15H,7-12,16-21H2,1-6H3 Key:ICLWTJIMXVISSR-UHFFFAOYSA-N
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Gallamine triethiodide (Flaxedil) is a non-depolarising muscle relaxant. It acts by combining with the cholinergic receptor sites in muscle and competitively blocking the transmitter action of acetylcholine. Gallamine triethiodide has a parasympatholytic effect on the cardiac vagus nerve which causes tachycardia and occasionally hypertension. Very high doses cause histamine release.

Gallamine triethiodide is commonly used to stabilize muscle contractions during surgical procedures.

It was developed by Daniel Bovet in 1947.

References

1. "Webster's Online Dictionary - Flaxedil". Retrieved 2008-12-15.
2. "RxMed: Pharmaceutical Information - FLAXEDIL". Retrieved 2008-12-15.
3. Raghavendra T (2002). "Neuromuscular blocking drugs: discovery and development". J R Soc Med. 95 (7): 363–7. doi:10.1258/jrsm.95.7.363. PMC 1279945. PMID 12091515. {{cite journal}}: Unknown parameter |month= ignored (help)

• Muscle relaxants
• Quaternary ammonium compounds
• Phenol ethers