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Argininosuccinic acid

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Argininosuccinic acid
Names
IUPAC name N-amino}(imino)methyl]-L-aspartic acid
Identifiers
3D model (JSmol)
ChemSpider
PubChem CID
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C10H18N4O6/c11-5(8(17)18)2-1-3-13-10(12)14-6(9(19)20)4-7(15)16/h5-6H,1-4,11H2,(H,15,16)(H,17,18)(H,19,20)(H3,12,13,14)/t5-,6-/m0/s1Key: KDZOASGQNOPSCU-WDSKDSINSA-N
  • InChI=1/C10H18N4O6/c11-5(8(17)18)2-1-3-13-10(12)14-6(9(19)20)4-7(15)16/h5-6H,1-4,11H2,(H,15,16)(H,17,18)(H,19,20)(H3,12,13,14)/t5-,6-/m0/s1Key: KDZOASGQNOPSCU-WDSKDSINBJ
SMILES
  • O=C(O)C(C(=O)O)NC(=N/CCC(N)C(=O)O)/N
Properties
Chemical formula C10H18N4O6
Molar mass 290.27312
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references
Chemical compound

Argininosuccinic acid is a chemical compound that is a basic amino acid.

Reactions

Some cells synthesize argininosuccinic acid from citrulline and aspartic acid and use it as a precursor for arginine in the urea cycle or citrulline-NO cycle. The enzyme that catalyzes the reaction is argininosuccinate synthetase.

Argininosuccinic acid is a precursor to fumarate in the citric acid cycle via argininosuccinate lyase.

See also

Urea cycle Metabolic Pathway

Carbamoyl phosphate

L-citrulline


Pi

L-ornithine

Urea

L-aspartate

+ ATP
PPi + AMP H2O

L-argininosuccinate

L-arginine

Fumarate

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