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Buparvaquone

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This is an old revision of this page, as edited by Beetstra (talk | contribs) at 16:13, 10 November 2011 (Script assisted update of identifiers for the Chem/Drugbox validation project (updated: 'ChEMBL', 'CAS_number').). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Revision as of 16:13, 10 November 2011 by Beetstra (talk | contribs) (Script assisted update of identifiers for the Chem/Drugbox validation project (updated: 'ChEMBL', 'CAS_number').)(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff) Pharmaceutical compound
Buparvaquone
Clinical data
ATCvet code
Identifiers
IUPAC name
  • 2-((4-tert-butylcyclohexyl)methyl)-3-hydroxy-1,4-naphthoquinone
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.115.556 Edit this at Wikidata
Chemical and physical data
FormulaC21H26O3
Molar mass326.435 g/mol g·mol
3D model (JSmol)
SMILES
  • CC(C)(C)C3CCC(C\C2=C(/O)C(=O)c1ccccc1C2=O)CC3
InChI
  • InChI=1S/C21H26O3/c1-21(2,3)14-10-8-13(9-11-14)12-17-18(22)15-6-4-5-7-16(15)19(23)20(17)24/h4-7,13-14,24H,8-12H2,1-3H3
  • Key:KLLIVCPQDTYMLC-UHFFFAOYSA-N
  (what is this?)  (verify)

Buparvaquone is a hydroxynaphthoquinone antiprotozoal drug related to parvaquone and atovaquone. It is a promising compound for the therapy and prophylaxis of all forms of theileriosis. Buparvaquone has been shown to have anti-leishmanial activity in vitro. It can be used to treat bovine East Coast fever protozoal in-vitro, along with the only other substance known - Peganum Harmala.

It is the only really efficient commercial therapy product in bovine theileriosis, where it is used since the late 1980s.

Industrial production

It was first produced in Great Britain, then in Germany. It came out of license in the mid 2000s, and was then produced in different countries, e.g. India and RAZAK labs co. of Iran

Use in bovine theileriosis

At unique dose of 2,5 mg/kg, recovery rate of curable cases is 90 to 98 %. In tropical theileriosis, a dosage of 2.0 mg/kg has the same efficiency. Body temperature returns to normal in two days (but only after 5 days in some cases). Parasitemia lowers from 12 % (D0) to 5 % (D1), than to 1 % (D5) and is nul at D7.

References

  1. Abou-El-Naga at al, Beni-Suef Vet. Med. J. 2005.


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