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This is an old revision of this page, as edited by Beetstra (talk | contribs) at 14:25, 6 December 2011 (Saving copy of the {{drugbox}} taken from revid 461256786 of page Sitagliptin for the Chem/Drugbox validation project (updated: '').). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

Revision as of 14:25, 6 December 2011 by Beetstra (talk | contribs) (Saving copy of the {{drugbox}} taken from revid 461256786 of page Sitagliptin for the Chem/Drugbox validation project (updated: '').)(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff)
This page contains a copy of the infobox ({{drugbox}}) taken from revid 461256786 of page Sitagliptin with values updated to verified values.
WikiProject Chemicals/Chembox validation/VerifiedDataSandbox
Clinical data
AHFS/Drugs.comMonograph
MedlinePlusa606023
License data
Routes of
administration		Oral
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability87%
Protein binding38%
MetabolismHepatic (CYP3A4- and CYP2C8-mediated)
Elimination half-life8 to 14 h
ExcretionRenal (80%)
Identifiers
IUPAC name
  • (R)-4-oxo-4-triazolopyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEBI
ChEMBL
Chemical and physical data
FormulaC16H15F6N5O
Molar mass407.314 g/mol g·mol
3D model (JSmol)
SMILES
  • Fc1cc(c(F)cc1F)C(N)CC(=O)N3Cc2nnc(n2CC3)C(F)(F)F
InChI
  • InChI=1S/C16H15F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2/t9-/m1/s1
  • Key:MFFMDFFZMYYVKS-SECBINFHSA-N
  (what is this?)  (verify)
  1. ^ Herman GA (2005). "Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: results from two randomized, double-blind, placebo-controlled studies with single oral doses". Clin Pharmacol Ther. 78 (6): 675–88. doi:10.1016/j.clpt.2005.09.002. PMID 16338283. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)