Misplaced Pages:WikiProject Chemicals/Chembox validation/VerifiedDataSandbox

This is an old revision of this page, as edited by Beetstra (talk | contribs) at 16:07, 6 December 2011 (Saving copy of the {{drugbox}} taken from revid 459771453 of page Sorafenib for the Chem/Drugbox validation project (updated: 'DrugBank').). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

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This page contains a copy of the infobox ({{drugbox}}) taken from revid 459771453 of page Sorafenib with values updated to verified values.

WikiProject Chemicals/Chembox validation/VerifiedDataSandbox
Clinical data


Trade names	Nexavar
Other names	Nexavar Sorafenib tosylate
AHFS/Drugs.com	Monograph
MedlinePlus	a607051
License data	EU EMA: by INN US FDA: Sorafenib
Pregnancy category	AU: D
Routes of administration	Oral
ATC code	L01XE05 (WHO)
Legal status
Legal status	US: ℞-only
Pharmacokinetic data
Bioavailability	29-49%
Protein binding	99.5%
Metabolism	Hepatic oxidation and glucuronidation (CYP3A4-mediated)
Elimination half-life	25–48 hours
Excretion	Fecal (77%) and renal (19%)
Identifiers
IUPAC name 4-carbamoylamino] phenoxy]-N-methyl-pyridine-2-carboxamide
CAS Number	284461-73-0
PubChem CID	216239
DrugBank	DB00398
ChemSpider	187440
UNII	9ZOQ3TZI87
KEGG	D08524
ChEBI	CHEBI:50924
ChEMBL	ChEMBL1336
Chemical and physical data
Formula	C₂₁H₁₆ClF₃N₄O₃
Molar mass	464.825 g/mol g·mol
3D model (JSmol)	Interactive image
SMILES CNC(=O)c1cc(ccn1)Oc2ccc(cc2)NC(=O)Nc3ccc(c(c3)C(F)(F)F)Cl
InChI InChI=1S/C21H16ClF3N4O3/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25/h2-11H,1H3,(H,26,30)(H2,28,29,31) Key:MLDQJTXFUGDVEO-UHFFFAOYSA-N
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