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Mangostin

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Mangostin
Names
IUPAC names 3,6,8-Trihydroxy-2-methoxy-1,7-
bis(3-methylbut-2-enyl)xanthen-9-one
Identifiers
CAS Number
3D model (JSmol)
ChEMBL
ChemSpider
ECHA InfoCard 100.208.637 Edit this at Wikidata
PubChem CID
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3Key: GNRIZKKCNOBBMO-UHFFFAOYSA-N
  • InChI=1/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3Key: GNRIZKKCNOBBMO-UHFFFAOYAL
SMILES
  • CC(=CCC1=C(C=C2C(=C1O)C(=O)C3=C
    (C(=C(C=C3O2)O)OC)CC=C(C)C)O)C
Properties
Chemical formula C24H26O6
Molar mass 410.45 g/mol
Appearance Yellow crystalline solid
Melting point 182 °C (360 °F; 455 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). ☒verify (what is  ?) Infobox references
Chemical compound

Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree (Garcinia mangostana). It is a yellow crystalline solid with a xanthone core structure. Mangostin and a variety of other xanthones from mangosteen have been investigated for biological properties including antioxidant, anti-bacterial, anti-inflammatory, and anticancer activities. In animal studies, mangostin has been found to be a central nervous system depressant which causes sedation, decreased motor activity, and ptosis.

The rind of partially ripe mangosteen fruit yields mangostin and also the related compound β-mangostin. The rind of fully ripe fruits contains the xanthonoids gartanin, 8-disoxygartanin and normangostin. A derivative of mangostin, mangostin-3,6-di-O-glucoside, is a central nervous system depressant and causes a rise in blood pressure.

References

  1. Jung H, Su B, Keller W, Mehta R, Kinghorn A (2006). "Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen)". J. Agric. Food Chem. 54 (6): 2077–82. doi:10.1021/jf052649z. PMID 16536578.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. Shankaranarayan D, Gopalakrishnan C, Kameswaran L. (1979). "Pharmacological profile of mangostin and its derivatives". Arch Int Pharmacodyn Ther. 239 (2): 257–269. PMID 314790.{{cite journal}}: CS1 maint: multiple names: authors list (link)
Types of xanthonoids
Aglycones
Glycosides
Acetylated
Misc.
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