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3-Phosphoglyceric acid

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3-Phosphoglyceric acid
Skeletal formula
Ball-and-stick model
Names
IUPAC name (2R)-2-Hydroxy-3-phosphonooxypropanoic acid
Identifiers
CAS Number
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
PubChem CID
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C3H7O7P/c4-2(3(5)6)1-10-11(7,8)9/h2,4H,1H2,(H,5,6)(H2,7,8,9)/t2-/m1/s1Key: OSJPPGNTCRNQQC-UWTATZPHSA-N
SMILES
  • C((C(=O)O)O)OP(=O)(O)O
Properties
Chemical formula C3H7O7P
Molar mass 186.06 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). ☒verify (what is  ?) Infobox references
Chemical compound

3-Phosphoglyceric acid (3PG), or glycerate 3-phosphate (GP), is a biochemically significant 3-carbon molecule that is a metabolic intermediate in both glycolysis and the Calvin cycle. This chemical is often termed PGA when referring to the Calvin cycle. 3-Phosphoglycerate is the resultant of the split of 6-carbon intermediate that is so unstable that it splits instantly. And two 3-phosphoglycerate molecules are produced for each molecule of CO2.

Glycolysis

Template:Biochemical Reaction Compound C00236 at KEGG Pathway Database. Enzyme 2.7.2.3 at KEGG Pathway Database. Compound C00197 at KEGG Pathway Database. Enzyme 5.4.2.1 at KEGG Pathway Database. Compound C00631 at KEGG Pathway Database.

Calvin cycle

In the Calvin cycle, two glycerate 3-phosphate molecules are reduced to form two molecules of glyceraldehyde 3-phosphate (PGAL). This is the first compound formed during the C3 or Calvin cycle. It is a reactive biomolecule that is easily reduced.

Amino acid synthesis

Glycerate 3-phosphate is also a precursor for serine, which, in turn, can create cysteine and glycine through the homocysteine cycle.

See also

Glycolysis metabolic pathway

Glucose

Hexokinase

ATP ADP Rightward reaction arrow with minor substrate(s) from top left and minor product(s) to top right

Glucose 6-phosphate

Glucose-6-phosphate
isomerase

Reversible left-right reaction arrow

Fructose 6-phosphate

Phosphofructokinase-1

ATP ADP Rightward reaction arrow with minor substrate(s) from top left and minor product(s) to top right

Fructose 1,6-bisphosphate

Fructose-bisphosphate
aldolase

Reversible left-right reaction arrow

Dihydroxyacetone phosphate

+

+

Glyceraldehyde 3-phosphate

Triosephosphate
isomerase

Reversible left-right reaction arrow

2 × Glyceraldehyde 3-phosphate

2 × 

Glyceraldehyde-3-phosphate
dehydrogenase

NAD+ Pi NADH + H Reversible left-right reaction arrow with minor forward substrate(s) from top left, minor forward product(s) to top right, minor reverse substrate(s) from bottom right and minor reverse product(s) to bottom leftNAD+ Pi NADH + H

2 × 1,3-Bisphosphoglycerate

2 × 

Phosphoglycerate kinase

ADP ATP Reversible left-right reaction arrow with minor forward substrate(s) from top left, minor forward product(s) to top right, minor reverse substrate(s) from bottom right and minor reverse product(s) to bottom leftADP ATP

2 × 3-Phosphoglycerate

2 × 

Phosphoglycerate mutase

Reversible left-right reaction arrow

2 × 2-Phosphoglycerate

2 × 

Phosphopyruvate
hydratase
(enolase)

  H2O Reversible left-right reaction arrow with minor forward product(s) to top right and minor reverse substrate(s) from bottom right  H2O

2 × Phosphoenolpyruvate

2 × 

Pyruvate kinase

ADP ATP Rightward reaction arrow with minor substrate(s) from top left and minor product(s) to top right

2 × Pyruvate

2 × 
Amino acid metabolism metabolic intermediates
Kacetyl-CoA
lysine
leucine
tryptophanalanine
G
G→pyruvate
citrate
glycine
serine
G→glutamate
α-ketoglutarate
histidine
proline
arginine
other
G→propionyl-CoA
succinyl-CoA
valine
isoleucine
methionine
threonine
propionyl-CoA
G→fumarate
phenylalaninetyrosine
G→oxaloacetate
Other
Cysteine metabolism
Glycine receptor modulators
Receptor
(ligands)
GlyRTooltip Glycine receptor
NMDARTooltip N-Methyl-D-aspartate receptor
Transporter
(blockers)
GlyT1Tooltip Glycine transporter 1
GlyT2Tooltip Glycine transporter 2
See also
Receptor/signaling modulators
GABA receptor modulators
GABAA receptor positive modulators
Ionotropic glutamate receptor modulators


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