This is an old revision of this page, as edited by CheMoBot (talk | contribs) at 22:58, 29 January 2012 (Updating {{drugbox}} (no changed fields - updated 'UNII_Ref', 'ChEMBL_Ref', 'ChEBI_Ref', 'KEGG_Ref', 'StdInChI_Ref', 'StdInChIKey_Ref', 'CAS_number_Ref') per Chem/Drugbox validation (report [[Misplaced Pages talk:WikiProject_Pharmacolog...). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.
Revision as of 22:58, 29 January 2012 by CheMoBot (talk | contribs) (Updating {{drugbox}} (no changed fields - updated 'UNII_Ref', 'ChEMBL_Ref', 'ChEBI_Ref', 'KEGG_Ref', 'StdInChI_Ref', 'StdInChIKey_Ref', 'CAS_number_Ref') per Chem/Drugbox validation (report [[Misplaced Pages talk:WikiProject_Pharmacolog...)(diff) ← Previous revision | Latest revision (diff) | Newer revision → (diff) Pharmaceutical compoundMonoclonal antibody | |
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Type | Whole antibody |
Source | Human |
Target | EpCAM |
Clinical data | |
ATC code |
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Identifiers | |
CAS Number | |
ChemSpider | |
Chemical and physical data | |
Formula | C6552H10080N1740O2052S46 |
Molar mass | 147.5 kDa g·mol |
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Adecatumumab (MT201) is a recombinant human monoclonal antibody which is used to target tumor cells. It binds to the epithelial cell adhesion molecule (EpCAM - CD326).
Adecatumumab has been used in clinical studies of treatment in prostate and breast cancers.
References
- Oberneder R, Weckermann D, Ebner B; et al. (2006). "A phase I study with adecatumumab, a human antibody directed against epithelial cell adhesion molecule, in hormone refractory prostate cancer patients". Eur. J. Cancer. 42 (15): 2530–8. doi:10.1016/j.ejca.2006.05.029. PMID 16930989.
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ignored (help)CS1 maint: multiple names: authors list (link) - Prang N, Preithner S, Brischwein K; et al. (2005). "Cellular and complement-dependent cytotoxicity of Ep-CAM-specific monoclonal antibody MT201 against breast cancer cell lines". Br. J. Cancer. 92 (2): 342–9. doi:10.1038/sj.bjc.6602310. PMC 2361858. PMID 15655555.
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