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An uncoupling protein is a mitochondrial inner membrane protein that can dissipate the proton gradient before it can be used to provide the energy for oxidative phosphorylation.

There are five types known in mammals:

• UCP1, also known as thermogenin
• UCP2
• UCP3
• SLC25A27, also known as "UCP4"
• SLC25A14, also known as "UCP5"

Uncoupling proteins play a role in normal physiology, as in hibernation, because the energy is used to generate heat (see thermogenesis) instead of producing ATP. However, other substances such as 2,4-Dinitrophenol and CCCP also serve the same uncoupling function, and are considered poisonous. Salicylic acid is also an uncoupling agent and will deplete the body of ATP and increase body temperature if taken in excess.

References

1. Nedergaard J, Ricquier D, Kozak LP (2005). "Uncoupling proteins: current status and therapeutic prospects". EMBO Rep. 6 (10): 917–21. doi:10.1038/sj.embor.7400532. PMC 1369193. PMID 16179945.{{cite journal}}: CS1 maint: multiple names: authors list (link)

External links

• Uncoupling+Agents at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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