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This article needs more reliable medical references for verification or relies too heavily on primary sources. Please review the contents of the article and add the appropriate references if you can. Unsourced or poorly sourced material may be challenged and removed. Find sources: "Spondylolisthesis" – news · newspapers · books · scholar · JSTOR (December 2008)

Spondylolisthesis
Specialty	Medical genetics, orthopedic surgery

Spondylolisthesis is the forward displacement of a vertebra, especially the fifth lumbar vertebra, most commonly occurring after a break or fracture. Backward displacement is referred to as retrolisthesis.

The variant "listhesis," resulting from division of this compound word, is sometimes applied in conjunction with scoliosis. These "slips" occur most commonly in the lumbar spine. Spondylolysis (a defect or fracture of the pars interarticularis of the vertebral arch) is the most common cause of spondylolisthesis, which should not be confused with a slipped disc, where one of the spinal discs in between the vertebrae has ruptured.

A hangman's fracture is a specific type of spondylolisthesis where the C2 vertebra is displaced anteriorly relative to the C3 vertebra due to fractures of the C2 vertebra's pedicles.

Classification

Spondylolisthesis is categorized into five types:

• Isthmic spondylolisthesis is the most common form; also called spondylolytic spondylolisthesis, it occurs with a reported prevalence of 5–7 percent in the US population. A slip or fracture of the intravertebral joint is usually acquired between the ages of 6 and 16 years, but remains unnoticed until adulthood. Roughly 90 percent of these isthmic slips are low-grade (less than 50 percent slip) and 10 percent are high-grade (greater than 50 percent slip).
• Degenerative spondylolisthesis is a disease of the older adult that develops as a result of facet arthritis and joint remodeling. Joint arthritis, and ligamentum flavum weakness, may result in slippage of a vertebrae. Degenerative forms are more likely to occur in women, persons older than fifty, and African-Americans.
• Traumatic spondylolisthesis is rare and results from acute fractures in the neural arch, other than the pars.
• Pathologic spondylolisthesis has been associated with damage to the posterior elements from metastases or metabolic bone disease. These slips have been reported in cases of Paget's disease of bone, tuberculosis, giant-cell tumors, and tumor metastases.
• Dysplastic spondylolisthesis is a rare congenital spondylolisthesis occurring because of a malformation of the lumbosacral junction resulting in small, incompetent facet joints.

Signs and symptoms

Symptoms of spondylolisthesis include:

• A general stiffening of the back and a tightening of the hamstrings, with a resulting change in both posture and gait.
• A leaning-forward or semi-kyphotic posture may be seen, due to compensatory changes.
• A "waddle" may be seen in more advanced causes, due to compensatory pelvic rotation due to decreased lumbar spine rotation.
• A result of the change in gait is often a noticeable atrophy in the gluteal muscles due to lack of use.
• Generalized lower-back pain may also be seen, with intermittent shooting pain from the buttocks to the posterior thigh, and/or lower leg via the sciatic nerve.

Other symptoms may include tingling and numbness. Coughing and sneezing can intensify the pain. An individual may also note a "slipping sensation" when moving into an upright position. Sitting and trying to stand up may be painful and difficult.

Treatment

Treatment of isthmic spondylolisthesis is controversial.

Conservative management

Patients with symptomatic isthmic spondylolisthesis are initially offered conservative treatment consisting of activity modification, pharmacological intervention, and a physical therapy consultation.

• Physical therapy can evaluate and address postural and compensatory movement abnormalities.
• Anti-inflammatory medications (NSAIDS) in combination with acetaminophen (Tylenol) can be tried initially. If a severe radicular component is present, a short course of oral steroids such as Prednisone or Methylprednisolone can be considered. Epidural steroid injections, either interlaminarl or transforaminal, performed under fluoroscopic guidance can help with severe radicular (leg) pain. Lumbosacral orthoses may be of benefit for some patients but should be used on a temporary basis to prevent spinal muscle atrophy and loss of proprioception.

Surgical

Degenerative spondylolisthesis with spinal stenosis is one of the most common indications for spine surgery among older adults.

History

Spondylolisthesis was first described in 1782 by Belgian obstetrician Herbinaux. He reported a bony prominence anterior to the sacrum that obstructed the vagina of a small number of patients. The term “spondylolisthesis” was coined in 1854 from the Greek σπονδυλος = "vertebra" and "ὁλισθος" = "slipperiness," "a slip."

See also

• Spondylosis
• Failed back syndrome

References

1. "Natural History of Adult Scoliosis".
2. ^ "Adult Spondylolisthesis in the Low Back". American Academy of Orthopaedic Surgeons. Retrieved 9 June 2013.
3. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2843565/
4. Newman PH (1955). "Spondylolisthesis: its cause and effect". Ann Coll Surg Engl. 16: 305.
5. Henry Jacques Garrigues (1902). A text-book of the science and art of obstetrics. pp. 490–93.
6. "Isthmic Spondylolisthesis and Spondylolysis".

• Articles needing additional medical references from December 2008
• Deforming dorsopathies
• Congenital disorders of musculoskeletal system