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Tobacco harm reduction (THR) is a public health strategy to lower the health risks associated with using nicotine. Smoking tobacco is widely acknowledged as a leading cause of illness and death. However, nicotine itself is not very harmful, as inferred from the long history of use for nicotine replacement therapy products. Thus, THR measures have been focused on reducing or eliminating the use of combustible tobacco by switching to other nicotine products, including:

1. Cutting down (either long-term or before quitting smoking)
2. Temporary abstinence
3. Switching to non-tobacco nicotine containing products, such as pharmaceutical nicotine replacement therapies or currently unlicensed products such as electronic cigarettes
4. Switching to Swedish or American smokeless tobacco products
5. Switching to non-combustible organic or additive-free tobacco products

It is widely acknowledged that discontinuation of all tobacco products confers the greatest lowering of risk. However, approved smoking cessation methods have a 90% failure rate, when used as directed. In addition, there is a considerable population of smokers who are unable or unwilling to achieve abstinence. Harm reduction is likely of substantial benefit to these smokers and public health.

History

The concept of tobacco harm reduction was established in 1976 when Professor Michael Russell wrote: "People smoke for nicotine but they die from the tar" and suggested that the ratio of tar to nicotine could be the key to safer smoking. Since then, the harm from smoking has been well-established as being caused almost exclusively by toxins released through the combustion of tobacco. In contrast, non-combustible tobacco products as well as pure nicotine products, although addictive, are considerably less harmful.

Debates on tobacco harm reduction tend to be geographically defined arguments, because of the varying legal, moral and historical status of tobacco, and the different types of tobacco and tobacco use in different cultures around the world. For instance, inhalant cigarette smoking is the dominant form in the United States, with a smaller number of users availing themselves of non-inhalant cigars, pipes, and smokeless tobacco. The political climate over the last few decades has led to both restrictions in the sale and use of tobacco and widespread information (and misinformation) about the negative health effects of tobacco use. Despite this, tobacco in all its forms has remained a legal product in most societies. A notable exception is the European Union, where the most dangerous products (cigarettes) are available but smokeless tobacco products, which are far less hazardous, are banned. The exception is Sweden, where there is a long tradition of smokeless tobacco use among men.

Harm reduction, a modality of dealing with other drug use, is beginning to be applied to tobacco use. In October 2008 the American Association of Public Health Physicians (AAPHP) became the first medical organization in the U.S. to officially endorse tobacco harm reduction as a viable strategy to reduce the death toll related to cigarette smoking. Joel Nitzkin, MD, of the AAPHP wrote: "So if we can figure that the nicotine in the e-cigarettes is basically a generic version of the same nicotine that is in prescription products, we have every reason to believe that the hazard posed by e-cigarettes would be much lower than one percent, probably lower than one tenth of one percent of the hazard posed by regular cigarettes."

"Safer cigarettes"

Cigarette manufacturers have attempted to design safer cigarettes for almost 50 years, but results have been marginal at best. Filters were introduced in the early 1950s, and manufacturers were selling low-yield cigarettes by the late 1960s. Initially it was thought that these innovations were harm reducing. For example, in 1976 investigators at the American Cancer Society published research concluding that light cigarettes were safer. The study authors wrote that "total death rates, death rates from coronary heart disease, and death rates from lung cancer were somewhat lower for those who smoked 'low' tar-nicotine cigarettes than for those who smoked 'high' tar-nicotine cigarettes."

Smokeless tobacco

It has been established that use of Swedish and American smokeless tobacco confers only 0.1% to 10% of the risks of smoking, though smokeless products in India and Asia contain higher levels of contaminants and thus confer greater risks. Two respected medical groups believe that smokeless tobacco may play a role in reducing smoking-attributable deaths. In 2007, Britain's Royal College of Physicians concluded "...that smokers smoke predominantly for nicotine, that nicotine itself is not especially hazardous, and that if nicotine could be provided in a form that is acceptable and effective as a cigarette substitute, millions of lives could be saved."

Electronic cigarettes

Electronic cigarettes are battery-powered devices that deliver vaporized propylene glycol or vegetable glycerin (or a mixture of both) and nicotine when users inhale while using them. Electronic cigarettes are a promising harm reduction technology because they deliver nicotine without the dangerous chemicals in tobacco smoke, while remaining attractive to smokers. While the regulatory status of e-cigarettes in many countries remains uncertain, public health advocates view electronic cigarette as having a valid place within tobacco harm reduction strategy. Public health researchers in the UK estimated that 6,000 premature smoking-related deaths per year would be prevented for every million smokers who switched to e-cigarettes. Since currently approved smoking cessation methods have a 90% failure rate, the use of e-cigarettes as a prominent THR modality is likely to substantially reduce tobacco-related illness in the United States.

Propellant-based nicotine delivery

An alternative nicotine delivery platform based on existing asthma inhaler technology is under development by a UK-based healthcare company, Kind Consumer Limited. The technology is currently under development and the company has submitted a Marketing Authorisation Application to the UK MHRA for licensing of the technology as an approved nicotine containing product. The technology is under licence to Nicoventures Limited a subsidiary of British American Tobacco who are responsible for the launch and commercialisation of the technology as an approved nicotine replacement therapy product.

Nicotine Pyruvate Technology

Philip Morris International bought the rights to a nicotine pyruvate technology developed by Jed Rose at Duke University. The technology is based around the chemical reaction between nicotine acid and a base which produces a nicotine pyruvate vapour for inhalation. It has undergone preliminary clinical evaluation which has shown delivery of nicotine to the lungs.

Controversy

Proponents of tobacco harm reduction assert that lessening the health risk for the individual user is worthwhile and manifests over the population in fewer tobacco-related illnesses and deaths. Opponents argue that some aspects of harm reduction interfere with cessation and abstinence and might increase initiation. Additionally, smokers remain confused about tobacco harm reduction. In a 2004 survey, about 80-100% of participants incorrectly perceived low-yield cigarettes as harm-reducing, while 75-80% mistakenly believed that switching to smokeless tobacco conferred no risk reduction.

See also

• Cancer Research UK Report on Tobacco Harm Reduction and Nicotine Containing Products (May 2013)
• History of commercial tobacco in the United States
• List of additives in cigarettes
• List of cigarette smoke carcinogens

References

1. ^ Nitzkin, J (June 2014). "The Case in Favor of E-Cigarettes for Tobacco Harm Reduction". Int J Environ Res Public Health. 11 (6): 6459–71. doi:10.3390/ijerph110606459. PMID 25003176. A carefully structured Tobacco Harm Reduction (THR) initiative, with e-cigarettes as a prominent THR modality, added to current tobacco control programming, is the most feasible policy option likely to substantially reduce tobacco-attributable illness and death in the United States over the next 20 years.{{cite journal}}: CS1 maint: unflagged free DOI (link)
2. ^ Fagerström, KO, Bridgman, K (March 2014). "Tobacco harm reduction: The need for new products that can compete with cigarettes". Addictive Behaviors. 39 (3): 507–511. doi:10.1016/j.addbeh.2013.11.002. PMID 24290207. The need for more appealing, licensed nicotine products capable of competing with cigarettes sensorially, pharmacologically and behaviourally is considered by many to be the way forward.{{cite journal}}: CS1 maint: multiple names: authors list (link)
3. ^ Template:Cite doi/10.1186.2F1477-7517-3-37
4. Russell, MA (June 1976). "Low-tar medium-nicotine cigarettes: a new approach to safer smoking". Br Med J. 1 (6023): 1430–3. PMID 953530.
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6. Update on the Scientific Status of Tobacco Harm Reduction, 2008-2010. Prepared for the American Association of Public Health Physicians. Brad Rodu, DDS and Joel L Nitzkin, MD. June 28, 2010.
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18. "New smoking cessation therapy proves promising". e! Science News. 2010-02-27.
19. Attention: This template ({{cite doi}}) is deprecated. To cite the publication identified by doi:10.1037/a0020834, please use {{cite journal}} (if it was published in a bona fide academic journal, otherwise {{cite report}} with |doi=10.1037/a0020834 instead.
20. Sumner W, 2005. Permissive nicotine regulation as a complement to traditional tobacco control. BMC Public Health 5:18.
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• Harm reduction
• Tobacco