Brain-specific angiogenesis inhibitor 3

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ADGRB3

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
4DLO

Identifiers

Aliases

ADGRB3, BAI3, adhesion G protein-coupled receptor B3

External IDs

OMIM: 602684; MGI: 2441837; HomoloGene: 1289; GeneCards: ADGRB3; OMA:ADGRB3 - orthologs

Gene location (Human)

Chr.	Chromosome 6 (human)

Band	6q12-q13	Start	68,635,282 bp
Band	6q12-q13	End	69,390,571 bp

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)

Band	1\|1 A5	Start	25,106,557 bp
Band	1\|1 A5	End	25,868,788 bp

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

middle temporal gyrus

endothelial cell

Brodmann area 23

ventricular zone

orbitofrontal cortex

superior frontal gyrus

Brodmann area 46

postcentral gyrus

entorhinal cortex

Region I of hippocampus proper

Top expressed in

lateral septal nucleus

nucleus accumbens

anterior amygdaloid area

olfactory tubercle

ventromedial nucleus

lobe of cerebellum

cerebellar vermis

medial geniculate nucleus

subiculum

Region I of hippocampus proper

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	G protein-coupled receptor activity protein binding transmembrane signaling receptor activity signal transducer activity GTPase activator activity
Cellular component	integral component of membrane plasma membrane membrane postsynapse synaptic cleft intracellular anatomical structure integral component of plasma membrane
Biological process	negative regulation of angiogenesis G protein-coupled receptor signaling pathway positive regulation of GTPase activity cell surface receptor signaling pathway myoblast fusion signal transduction positive regulation of synapse assembly regulation of dendrite morphogenesis motor learning maintenance of synapse structure neuron remodeling adenylate cyclase-activating G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


577


210933

Ensembl


ENSG00000135298


ENSMUSG00000033569

UniProt


O60242


Q80ZF8

RefSeq (mRNA)


NM_001704


NM_175642

RefSeq (protein)


NP_001695


NP_783573

Location (UCSC)

Chr 6: 68.64 – 69.39 Mb

Chr 1: 25.11 – 25.87 Mb

PubMed search

Wikidata

View/Edit Human

View/Edit Mouse

Brain-specific angiogenesis inhibitor 3 is a protein that in humans is encoded by the BAI3 gene.

Template:PBB Summary

The adhesion GPCR BaI3 is an orphan receptor that has a long N-terminus consisting of one cub domain, five BaI Thrombospondin type 1 repeats, and one hormone binding domain. BaI3 is expressed in neural tissues of the central nervous system. BaI3 has been shown to have a high affinity for C1q proteins. C1q added to hippocampal neurons expressing BaI3 resulted in a decrease in the number of synapses.

References

^ GRCh38: Ensembl release 89: ENSG00000135298 – Ensembl, May 2017
^ GRCm38: Ensembl release 89: ENSMUSG00000033569 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T (Apr 1998). "Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)". Cytogenet Cell Genet. 79 (1–2): 103–8. doi:10.1159/000134693. PMID 9533023.
"Entrez Gene: BAI3 brain-specific angiogenesis inhibitor 3".
Marc F. Bolliger, David C. Martinelli, and Thomas C. Südhof. The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins. PNAS 2011 ; published ahead of print January 24, 2011, doi:10.1073/pnas.1019577108

External links

Human ADGRB3 genome location and ADGRB3 gene details page in the UCSC Genome Browser.

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2), EP (1 2 3 4), FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2, GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Anaphylatoxin (C3a
C5a (1
2))
Angiotensin (1
2)
Apelin
Bombesin
- BRS3
- GRPR
- NMBR)
- Bradykinin (B1
- B2)
Chemokine
Cholecystokinin (A
B)
Endothelin
- A
- B
Formyl peptide (1
2
3)
FSH
Galanin (1
2
3)
Gonadotropin-releasing hormone (1
2)
Ghrelin
Kisspeptin
Luteinizing hormone/choriogonadotropin
MAS (1
1L
D
E
F
G
X1
X2
X3
X4)
Melanocortin (1
2
3
4
5)
MCHR (1
2)
Motilin
Opioid (Delta
Kappa
Mu
Nociceptin & Zeta, but not Sigma)
Orexin (1
2)
Oxytocin
Prokineticin (1
2)
Prolactin-releasing peptide
Relaxin (1
2
3
4)
Somatostatin (1
2
3
4
5)
Tachykinin (1
2
3)
Thyrotropin
Thyrotropin-releasing hormone
Urotensin-II
Vasopressin (1A
1B
2)

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B: Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C: Metabotropic glutamate / pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F: Frizzled & Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)
Smoothened	Smoothened

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References

External links

Further reading