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APTX 4869 is a fictional poison in the anime and manga Case Closed.
The toxin is a derivative of an experimental immortality formula, adapted by Sherry to function as an untraceable, lethal poison.
APTX is an abbreviation of "Apoptoxin," and, as the name implies, it involves the activation of uncontrolled apoptosis which causes death by the destruction of cells. In addition, it can also activate telomerase.
The poison is designed to be untraceable in its victims. However, in very rare cases, it causes the apoptosis of non-neural cells only and the apoptosis would stabilise at some point, causing the victim's apparent age to be decreased. Conan Edogawa, the series' protagonist, is such a victim; later Shiho Miyano, who chooses to attempt suicide by using her own drug, was added to the very short list of people not killed by APTX-4869.
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