| Revision as of 17:01, 16 February 2012 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Saving copy of the {{chembox}} taken from revid 465591173 of page 2,4,6-Trihydroxyacetophenone for the Chem/Drugbox validation project (updated: 'CASNo'). |
Latest revision as of 02:11, 1 July 2022 edit Citation bot (talk | contribs)Bots5,424,145 edits Add: pmid. | Use this bot. Report bugs. | Suggested by Abductive | Category:Multiple chemicals in an infobox that need indexing | #UCB_Category 1576/1863 |
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{{ambox | text = This page contains a copy of the infobox ({{tl|chembox}}) taken from revid of page ] with values updated to verified values.}} |
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{{chembox |
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{{chembox |
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| Watchedfields = changed |
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| Watchedfields = changed |
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| verifiedrevid = 412502710 |
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| verifiedrevid = 477210870 |
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| ImageFile = 2,4,6-Trihydroxyacetophenone.svg |
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| ImageFile = 2,4,6-Trihydroxyacetophenone.svg |
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| ImageSize = 180px |
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| ImageSize = 180px |
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| ImageSize1 = 180px |
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| ImageSize1 = 180px |
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| ImageName1 = Ball-and-stick model |
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| ImageName1 = Ball-and-stick model |
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|IUPACName= 1-(2,4,6-trihydroxyphenyl)ethanone |
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| PIN = 1-(2,4,6-Trihydroxyphenyl)ethan-1-one |
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|OtherNames= 2-Acetylphloroglucinol<br>THAP<br>Phloroacetophenone |
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| OtherNames = 1-(2,4,6-Trihydroxyphenyl)ethanone<br />2-Acetylphloroglucinol<br />THAP<br />Phloroacetophenone |
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|Reference= |
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| Reference = |
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|Section1= {{Chembox Identifiers |
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|Section1={{Chembox Identifiers |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| CASNo_Ref = {{cascite|correct|CAS}} |
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| CASNo =480-66-0 |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID = 61386 |
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| ChemSpiderID = 61386 |
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| ChEBI_Ref = {{ebicite|correct|EBI}} |
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| InChI = 1/C8H8O4/c1-4(9)8-6(11)2-5(10)3-7(8)12/h2-3,10-12H,1H3 |
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| ChEBI = 64344 |
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| InChIKey = XLEYFDVVXLMULC-UHFFFAOYAA |
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| SMILES1 = O=C(c1c(O)cc(O)cc1O)C |
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| ChEMBL_Ref = {{ebicite|correct|EBI}} |
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| ChEMBL_Ref = {{ebicite|correct|EBI}} |
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| ChEMBL = 452477 |
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| ChEMBL = 452477 |
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| EC_number = 207-556-5 |
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| KEGG = C21895 |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII = 8L7XD8830T |
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| PubChem = 68073 |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI = 1S/C8H8O4/c1-4(9)8-6(11)2-5(10)3-7(8)12/h2-3,10-12H,1H3 |
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| StdInChI = 1S/C8H8O4/c1-4(9)8-6(11)2-5(10)3-7(8)12/h2-3,10-12H,1H3 |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey = XLEYFDVVXLMULC-UHFFFAOYSA-N |
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| StdInChIKey = XLEYFDVVXLMULC-UHFFFAOYSA-N |
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| InChI = 1/C8H8O4/c1-4(9)8-6(11)2-5(10)3-7(8)12/h2-3,10-12H,1H3 |
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| CASNo_Ref = {{cascite|correct|??}}= |
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| InChIKey = XLEYFDVVXLMULC-UHFFFAOYAA |
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| CASNo = <!-- blanked - oldvalue: 480-66-0 --> |
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| SMILES1 = O=C(c1c(O)cc(O)cc1O)C |
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| PubChem= |
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| SMILES= CC(=O)c1c(cc(cc1O)O)O |
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| SMILES = CC(=O)c1c(cc(cc1O)O)O |
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}} |
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|Section2= {{Chembox Properties |
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| C=8|H=8|O=4 |
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| Appearance= |
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| Density= |
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| MeltingPt=219–221 °C |
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| BoilingPt= |
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| Solubility= |
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}} |
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}} |
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|Section3= {{Chembox Hazards |
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|Section2={{Chembox Properties |
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| C=8 | H=8 | O=4 |
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| MainHazards= |
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| Appearance = |
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| FlashPt= |
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| Density = |
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| MeltingPtC = 219 to 221 |
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| MeltingPt_notes = |
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|Section3={{Chembox Hazards |
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| GHSPictograms = {{GHS07}} |
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| GHSSignalWord = Warning |
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| HPhrases = {{H-phrases|315|319|335}} |
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| PPhrases = {{P-phrases|261|264|271|280|302+352|304+340|305+351+338|312|321|332+313|337+313|362|403+233|405|501}} |
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| MainHazards = |
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| FlashPt = |
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| AutoignitionPt = |
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}} |
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}} |
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'''2,4,6-Trihydroxyacetophenone''' (THAP) is a chemical compound that is a ] of ]. |
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In an animal model, THAP was reported to enhance ] (CYP7A1) activity.<ref>{{cite journal | doi = 10.1016/j.ejphar.2005.03.039| pmid = 15896733| title = Induction of human cholesterol 7α-hydroxylase in HepG2 cells by 2,4,6-trihydroxyacetophenone| journal = European Journal of Pharmacology| volume = 515| issue = 1–3| pages = 43–46| year = 2005| last1 = Charoenteeraboon| first1 = Juree| last2 = Nithipatikom| first2 = Kasem| last3 = Campbell| first3 = William B.| last4 = Piyachaturawat| first4 = Pawinee| last5 = Wilairat| first5 = Prapon| last6 = Rongnoparut| first6 = Pornpimol}}</ref> |
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THAP is also used as a matrix in ] (MALDI) for the analysis of acidic ]s and ]s in negative ion mode. |
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==Derivatives== |
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THAP is a ] that can be used to form part of the backbone of 5,7-dihydroxyflavones like ],<ref name="BruderHaseler2010">{{cite journal|last1=Bruder|first1=Marjorie|last2=Haseler|first2=Paul L.|last3=Muscarella|first3=Marina|last4=Lewis|first4=William|last5=Moody|first5=Christopher J.|title=Synthesis of the Oxepinochromone Natural Products Ptaeroxylin (Desoxykarenin), Ptaeroxylinol, and Eranthin|journal=The Journal of Organic Chemistry|volume=75|issue=2|year=2010|pages=353–358|issn=0022-3263|doi=10.1021/jo902117e|pmid=20000660 }}</ref> ], ], ], ], and ]. |
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==See also== |
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*] |
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==References== |
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{{reflist}} |
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{{DEFAULTSORT:Trihydroxyacetophenone, 2,4,6-}} |
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] |
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] |
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] |