| Revision as of 18:15, 16 February 2012 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Saving copy of the {{drugbox}} taken from revid 452189620 of page 4-Hydroxy-4-methylpentanoic_acid for the Chem/Drugbox validation project (updated: 'CAS_number'). |
Latest revision as of 04:34, 25 March 2024 edit DMacks (talk | contribs)Edit filter managers, Autopatrolled, Administrators186,015 edits auto mw |
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{{Short description|Chemical compound}} |
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{{ambox | text = This page contains a copy of the infobox ({{tl|drugbox}}) taken from revid of page ] with values updated to verified values.}} |
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{{Drugbox |
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{{Drugbox |
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| Verifiedfields = changed |
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| verifiedrevid = 447616705 |
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| verifiedrevid = 477222148 |
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| IUPAC_name = 4-Hydroxy-4-methylpentanoic acid |
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| IUPAC_name = 4-Hydroxy-4-methylpentanoic acid |
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| image = 4-Hydroxy-4-methylpentanoic acid.svg |
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| image = 4-Hydroxy-4-methylpentanoic acid.svg |
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<!--Identifiers--> |
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<!--Identifiers--> |
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| CAS_number_Ref = {{cascite|correct|CAS}} |
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| CAS_number = <!-- blanked - oldvalue: 23327-19-7 --> |
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| CAS_number = 23327-19-7 |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII = RBT229QVC5 |
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| ATC_prefix = |
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| ATC_prefix = |
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| ATC_suffix = |
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| ATC_suffix = |
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| chemical_formula = |
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| chemical_formula = |
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| C=6 | H=12 | Br= | Cl= | Co= | F= | I= | N= | Na= | O=3 | P= | S= | Se= | charge = |
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| C=6 | H=12 | Br= | Cl= | Co= | F= | I= | N= | Na= | O=3 | P= | S= | Se= | charge = |
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| molecular_weight = 132.16 |
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| smiles = OC(CCC(C)(O)C)=O |
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| smiles = OC(CCC(C)(O)C)=O |
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| InChI = 1/C6H12O3/c1-6(2,9)4-3-5(7)8/h9H,3-4H2,1-2H3,(H,7,8) |
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| InChIKey = PQJUMPXLDAZULJ-UHFFFAOYAC |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI = 1S/C6H12O3/c1-6(2,9)4-3-5(7)8/h9H,3-4H2,1-2H3,(H,7,8) |
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| StdInChI = 1S/C6H12O3/c1-6(2,9)4-3-5(7)8/h9H,3-4H2,1-2H3,(H,7,8) |
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| sec_combustion = |
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| sec_combustion = |
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}} |
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}} |
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'''4-Hydroxy-4-methylpentanoic acid''' ('''UMB68''') is a tertiary alcohol, similar in structure to the drug ]. The molecule has been synthesized and tested on animals in order to further research the effects of GHB. UMB68 has been shown to bind selectively to the ] ligand in binding assays, yet does not bind to ] receptors. As such, it can provide a useful tool in studying the pharmacology of the GHB receptor in absence of GABAergic effects.<ref>{{cite journal | vauthors = Wu H, Zink N, Carter LP, Mehta AK, Hernandez RJ, Ticku MK, Lamb R, France CP, Coop A | title = A Tertiary Alcohol Analog of γ-Hydroxybutyric Acid as a Specific γ-Hydroxybutyric Acid Receptor Ligand | journal = Journal of Pharmacology and Experimental Therapeutics | year = 2003 | volume = 305 | issue = 2 | pages = 675–679 | doi = 10.1124/jpet.102.046797 | pmid = 12606613 | s2cid = 86191608 | url=http://jpet.aspetjournals.org/cgi/content/full/305/2/675 }}</ref> |
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==References== |
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{{Reflist|2}} |
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{{GHBergics}} |
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{{DEFAULTSORT:Hydroxy-4-methylpentanoic acid, 4-}} |
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] |
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] |
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] |
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] |
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{{nervous-system-drug-stub}} |