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Revision as of 15:06, 6 August 2011 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Script assisted update of identifiers for the Chem/Drugbox validation project (updated: 'ChEBI').← Previous edit		Latest revision as of 01:51, 19 August 2023 edit undoOAbot (talk | contribs)Bots439,234 editsm Open access bot: doi updated in citation with #oabot.
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			{{Correct title|7,12-Dimethylbenzanthracene|reason=bracket|edit=substitution}}
		⚫	{{DISPLAYTITLE:7,12-Dimethylbenz(''a'')anthracene}}
	{{chembox		{{chembox
			| Watchedfields = changed
	| verifiedrevid = 413285462
	|Reference=<ref> at ]</ref>		| Name=7,12-Dimethylbenzanthracene
			| verifiedrevid = 477226290
			| Reference=<ref> at ]</ref>
	|ImageFile1=DMBA.png		| ImageFile1=DMBA.png
		⚫	| ImageFile2=7,12-Dimethylbenz(a)anthracene_ballstick.png
	|ImageSize1=200px
			| PIN = 7,12-Dimethyltetraphene
⚫	|ImageFile2=7,12-Dimethylbenz(a)anthracene_ballstick.png
			| OtherNames = 7,12-Dimethylbenzophenanthrene<br />7,12-Dimethylbenzanthracene<br />7,12-Dimethyltetraphene<br />1,4-Dimethyl-2,3-benzophenanthrene
	|ImageSize1=200px
	|IUPACName=7,12-dimethylbenzophenanthrene
	|OtherNames=
	|Section1={{Chembox Identifiers		|Section1={{Chembox Identifiers
		⚫	| CASNo=57-97-6
⚫	| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
		⚫	| CASNo_Ref = {{cascite|correct|CAS}}
			| Beilstein = 1912135
		⚫	| ChEBI_Ref = {{ebicite|correct|EBI}}
		⚫	| ChEBI = 254496
			| ChEMBL_Ref = {{ebicite|correct|EBI}}
		⚫	| ChEMBL = 329673
		⚫	| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
	| ChemSpiderID = 5779		| ChemSpiderID = 5779
			| Gmelin = 263937
			| KEGG = C19488
		⚫	| PubChem=6001
			| RTECS = CW3850000
			| UNNumber = 3077
			| UNII_Ref = {{fdacite|correct|FDA}}
			| UNII = F05B6S0395
	| InChI = 1/C20H16/c1-13-16-8-5-6-9-17(16)14(2)20-18(13)12-11-15-7-3-4-10-19(15)20/h3-12H,1-2H3		| InChI = 1/C20H16/c1-13-16-8-5-6-9-17(16)14(2)20-18(13)12-11-15-7-3-4-10-19(15)20/h3-12H,1-2H3
	| InChIKey = ARSRBNBHOADGJU-UHFFFAOYAX		| InChIKey = ARSRBNBHOADGJU-UHFFFAOYAX
⚫	| ChEMBL_Ref = {{ebicite|correct|EBI}}
⚫	| ChEMBL = 329673
	| StdInChI_Ref = {{stdinchicite|correct|chemspider}}		| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
	| StdInChI = 1S/C20H16/c1-13-16-8-5-6-9-17(16)14(2)20-18(13)12-11-15-7-3-4-10-19(15)20/h3-12H,1-2H3		| StdInChI = 1S/C20H16/c1-13-16-8-5-6-9-17(16)14(2)20-18(13)12-11-15-7-3-4-10-19(15)20/h3-12H,1-2H3
	| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}		| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
	| StdInChIKey = ARSRBNBHOADGJU-UHFFFAOYSA-N		| StdInChIKey = ARSRBNBHOADGJU-UHFFFAOYSA-N
⚫	| CASNo=57-97-6
⚫	| CASNo_Ref = {{cascite|correct|CAS}}
⚫	| PubChem=6001
⚫	| ChEBI = 254496
	| SMILES = c32c(c1ccccc1c(c2ccc4c3cccc4)C)C		| SMILES = c32c(c1ccccc1c(c2ccc4c3cccc4)C)C
	}}		}}
	|Section2={{Chembox Properties		|Section2={{Chembox Properties
	| Formula=C<sub>20</sub>H<sub>16</sub>		| C=20 | H=16
			| Appearance=
	| MolarMass=256.34104
	| Appearance=		| Density=
			| MeltingPtC=122 to 123
	| Density=
			| BoilingPt=
	| MeltingPt=122-123 °C
	| BoilingPt=		| Solubility=
	| Solubility=
	}}		}}
	|Section3={{Chembox Hazards		|Section3={{Chembox Hazards
	| MainHazards=T (Toxic)		| MainHazards=T (Toxic)
	| FlashPt=		| FlashPt=
			| AutoignitionPt =
	| Autoignition=
	| RPhrases={{R45}} {{R22}}		| GHSPictograms = {{GHS07}}{{GHS08}}
			| GHSSignalWord = Danger
	| SPhrases={{S53}} {{S36/37}} {{S45}}
			| HPhrases = {{H-phrases|302|350}}
			| PPhrases = {{P-phrases|201|202|264|270|281|301+312|308+313|330|405|501}}
			| NFPA-H = 2
			| NFPA-R = 0
			| NFPA-F = 0
			| NFPA-S =
	}}		}}
	}}		}}
	'''7,12-Dimethylbenz(a)anthracene''' is an ] and a powerful organ-specific laboratory ].<ref>Miyata M, Furukawa M, Takahashi K, Gonzalez FJ, Yamazoe Y. (2001) Mechanism of 7, 12-Dimethylbenzanthracene-Induced Immunotoxicity: Role of Metabolic Activation at the Target Organ. Jpn J Pharmacol 86:302-309. </ref> Also known as 7,12-dimethylbenzanthracene or DMBA, this substance is widely used in many research laboratories studying cancer. DMBA serves as a ] by making necessary mutations. ] can be induced with treatments of TPA (]) in some models of two-stage carcinogenesis.<ref>Sung YM, He G, Fischer, SM. (2005) Lack of Expression of the EP2 but not EP3 Receptor for Prostaglandin E2 Results in Suppression of Skin Tumor Development. Cancer Res 65:9304-9311</ref> This allows for a greatly accelerated rate of tumor growth, making many cancer studies possible.		'''7,12-Dimethylbenzanthracene''' ('''DMBA''') is an ] and a powerful organ-specific laboratory ].<ref>{{cite journal |author=Miyata M |author2=Furukawa M |author3=Takahashi K |author4=Gonzalez FJ |author5=Yamazoe Y |title=Mechanism of 7, 12-Dimethylbenzanthracene-Induced Immunotoxicity: Role of Metabolic Activation at the Target Organ |journal=Jpn J Pharmacol |date=2001 |volume=86 |issue=3 |pages=302–309 |doi=10.1254/jjp.86.302 |pmid=11488430 |doi-access=free }}</ref> DMBA is widely used in many research laboratories studying cancer. DMBA serves as a ]. ] can be induced with treatments of ] (TPA) in some models of two-stage carcinogenesis.<ref>{{cite journal | author = Sung YM | author2 = He G | author3 = Fischer, SM | date = 2005 | title = Lack of Expression of the EP2 but not EP3 Receptor for Prostaglandin E2 Results in Suppression of Skin Tumor Development | journal = Cancer Res | volume = 65 | issue = 20 | pages = 9304–9311 | doi=10.1158/0008-5472.can-05-1015| pmid = 16230392 | doi-access = }}</ref> This allows for a greatly accelerated rate of tumor growth, making many cancer studies possible.
	==References==		==References==
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