| Revision as of 18:39, 16 February 2012 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Saving copy of the {{chembox}} taken from revid 465224233 of page 7,12-Dimethylbenz(a)anthracene for the Chem/Drugbox validation project (updated: ''). |
Latest revision as of 01:51, 19 August 2023 edit OAbot (talk | contribs)Bots439,234 editsm Open access bot: doi updated in citation with #oabot. |
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{{Correct title|7,12-Dimethylbenzanthracene|reason=bracket|edit=substitution}} |
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{{ambox | text = This page contains a copy of the infobox ({{tl|chembox}}) taken from revid of page ] with values updated to verified values.}} |
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{{DISPLAYTITLE:7,12-Dimethylbenz(''a'')anthracene}} |
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{{chembox |
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{{chembox |
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| Watchedfields = changed |
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| Watchedfields = changed |
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| Name=7,12-Dimethylbenzanthracene |
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| verifiedrevid = 443356518 |
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| verifiedrevid = 477226290 |
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|Reference=<ref> at ]</ref> |
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| Reference=<ref> at ]</ref> |
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|ImageFile1=DMBA.png |
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| ImageFile1=DMBA.png |
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|ImageSize1=200px |
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|ImageFile2=7,12-Dimethylbenz(a)anthracene_ballstick.png |
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| ImageFile2=7,12-Dimethylbenz(a)anthracene_ballstick.png |
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| PIN = 7,12-Dimethyltetraphene |
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|ImageSize1=200px |
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| OtherNames = 7,12-Dimethylbenzophenanthrene<br />7,12-Dimethylbenzanthracene<br />7,12-Dimethyltetraphene<br />1,4-Dimethyl-2,3-benzophenanthrene |
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|IUPACName=7,12-dimethylbenzophenanthrene |
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|OtherNames= |
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|Section1={{Chembox Identifiers |
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|Section1={{Chembox Identifiers |
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| CASNo=57-97-6 |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| CASNo_Ref = {{cascite|correct|CAS}} |
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| Beilstein = 1912135 |
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| ChEBI_Ref = {{ebicite|correct|EBI}} |
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| ChEBI = 254496 |
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| ChEMBL_Ref = {{ebicite|correct|EBI}} |
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| ChEMBL = 329673 |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID = 5779 |
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| ChemSpiderID = 5779 |
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| Gmelin = 263937 |
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| KEGG = C19488 |
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| PubChem=6001 |
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| RTECS = CW3850000 |
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| UNNumber = 3077 |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| UNII = F05B6S0395 |
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| InChI = 1/C20H16/c1-13-16-8-5-6-9-17(16)14(2)20-18(13)12-11-15-7-3-4-10-19(15)20/h3-12H,1-2H3 |
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| InChI = 1/C20H16/c1-13-16-8-5-6-9-17(16)14(2)20-18(13)12-11-15-7-3-4-10-19(15)20/h3-12H,1-2H3 |
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| InChIKey = ARSRBNBHOADGJU-UHFFFAOYAX |
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| InChIKey = ARSRBNBHOADGJU-UHFFFAOYAX |
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| ChEMBL_Ref = {{ebicite|correct|EBI}} |
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| ⚫ |
| ChEMBL = 329673 |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI = 1S/C20H16/c1-13-16-8-5-6-9-17(16)14(2)20-18(13)12-11-15-7-3-4-10-19(15)20/h3-12H,1-2H3 |
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| StdInChI = 1S/C20H16/c1-13-16-8-5-6-9-17(16)14(2)20-18(13)12-11-15-7-3-4-10-19(15)20/h3-12H,1-2H3 |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey = ARSRBNBHOADGJU-UHFFFAOYSA-N |
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| StdInChIKey = ARSRBNBHOADGJU-UHFFFAOYSA-N |
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| CASNo=57-97-6 |
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| ⚫ |
| CASNo_Ref = {{cascite|correct|CAS}} |
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| PubChem=6001 |
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| ChEBI_Ref = {{ebicite|correct|EBI}} |
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| ChEBI = 254496 |
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| SMILES = c32c(c1ccccc1c(c2ccc4c3cccc4)C)C |
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| SMILES = c32c(c1ccccc1c(c2ccc4c3cccc4)C)C |
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}} |
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|Section2={{Chembox Properties |
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|Section2={{Chembox Properties |
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| Formula=C<sub>20</sub>H<sub>16</sub> |
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| C=20 | H=16 |
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| Appearance= |
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| MolarMass=256.34104 |
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| Appearance= |
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| Density= |
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| MeltingPtC=122 to 123 |
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| Density= |
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| BoilingPt= |
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| MeltingPt=122–123 °C |
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| BoilingPt= |
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| Solubility= |
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| Solubility= |
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}} |
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}} |
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|Section3={{Chembox Hazards |
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|Section3={{Chembox Hazards |
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| MainHazards=T (Toxic) |
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| MainHazards=T (Toxic) |
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| FlashPt= |
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| FlashPt= |
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| AutoignitionPt = |
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| Autoignition= |
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| RPhrases={{R45}} {{R22}} |
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| GHSPictograms = {{GHS07}}{{GHS08}} |
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| GHSSignalWord = Danger |
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| SPhrases={{S53}} {{S36/37}} {{S45}} |
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| HPhrases = {{H-phrases|302|350}} |
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| PPhrases = {{P-phrases|201|202|264|270|281|301+312|308+313|330|405|501}} |
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| NFPA-H = 2 |
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| NFPA-R = 0 |
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| NFPA-F = 0 |
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| NFPA-S = |
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}} |
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}} |
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'''7,12-Dimethylbenzanthracene''' ('''DMBA''') is an ] and a powerful organ-specific laboratory ].<ref>{{cite journal |author=Miyata M |author2=Furukawa M |author3=Takahashi K |author4=Gonzalez FJ |author5=Yamazoe Y |title=Mechanism of 7, 12-Dimethylbenzanthracene-Induced Immunotoxicity: Role of Metabolic Activation at the Target Organ |journal=Jpn J Pharmacol |date=2001 |volume=86 |issue=3 |pages=302–309 |doi=10.1254/jjp.86.302 |pmid=11488430 |doi-access=free }}</ref> DMBA is widely used in many research laboratories studying cancer. DMBA serves as a ]. ] can be induced with treatments of ] (TPA) in some models of two-stage carcinogenesis.<ref>{{cite journal | author = Sung YM | author2 = He G | author3 = Fischer, SM | date = 2005 | title = Lack of Expression of the EP2 but not EP3 Receptor for Prostaglandin E2 Results in Suppression of Skin Tumor Development | journal = Cancer Res | volume = 65 | issue = 20 | pages = 9304–9311 | doi=10.1158/0008-5472.can-05-1015| pmid = 16230392 | doi-access = }}</ref> This allows for a greatly accelerated rate of tumor growth, making many cancer studies possible. |
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==References== |
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{{reflist}} |
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{{DEFAULTSORT:Dimethylbenz(a)anthracene, 7,12-}} |
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] |
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