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{{Short description|A combination of antihypertensive drugs used to treat hypertension}} |
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An ] and ] combination is a ] used to treat ] (high blood pressure). They are given ]. ACE inhibitors reduce the activity of ] (ACE) which produces ], a hormone that constricts blood vessels. Thiazides are a class of diuretics that inhibit the ], thereby increasing urine production and reducing excess water and salt in the body. Several organizations recommend combination therapy for hypertension in cases of failure of a single drug to achieve target blood pressure, or even as a first line treatment for some patients.<ref>{{cite web|title=Choice of drug therapy in primary (essential) hypertension|url=https://www.uptodate.com/contents/choice-of-drug-therapy-in-primary-essential-hypertension/print}}</ref> |
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==Examples== |
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{{Drugbox |
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{{Drugbox |
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<!--Combo data--> |
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| verifiedrevid = 437098836 |
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| drug_name = Quinapril/hydrochlorothiazide |
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| type = combo |
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| component1 = Quinapril |
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| class1 = ] |
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| component2 = Hydrochlorothiazide |
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| class2 = ] ] |
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<!--Clinical data--> |
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| tradename = Accuretic |
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| MedlinePlus = |
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| Drugs.com = {{Drugs.com|MTM|accuretic}} |
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| licence_EU = <!-- EMEA requires brand name --> |
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| licence_US = |
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| pregnancy_AU = |
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| pregnancy_US = D |
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| pregnancy_category = |
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| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> |
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| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C --> |
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| legal_US = Rx-only |
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| legal_status = |
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| dependency_liability = |
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| routes_of_administration = |
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<!--Identifiers--> |
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| CAS_number = |
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| ATC_prefix = C09 |
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| ATC_suffix = BA06 |
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| PubChem = |
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| KEGG = D10278 |
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| ChemSpiderID = 30797396 |
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}}{{Drugbox |
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| verifiedrevid = 447439314 |
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<!--Combo data--> |
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<!--Combo data--> |
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| drug_name = Lisinopril/hydrochlorothiazide |
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| type = combo |
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| type = combo |
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| component1 = Lisinopril |
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| component1 = Lisinopril |
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| ATC_prefix = C09 |
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| ATC_prefix = C09 |
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| ATC_suffix = BA03 |
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| ATC_suffix = BA03 |
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| KEGG = D10268 |
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<!--Chemical data--> |
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<!--Chemical data--> |
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}} |
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}}'''Lisinopril/hydrochlorothiazide''' (trade name '''Prinzide''' by ], '''Zestoretic''' by ], and many others) is a combination of the drugs ], an ], and ], a ]. It is used to control ]. |
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*] (trade name Enalapril comp), wherein enalapril is the ACE inhibitor and hydrochlorothiazide is the thiazide. |
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*]/hydrochlorothiazide (trade name Accuretic)<ref>Accuretic {{Drugs.com|MTM|accuretic}}</ref> |
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*] is marketed as Prinzide,<ref>{{cite web|url=https://www.drugs.com/mtm/prinzide.html|title=Prinzide Uses, Side Effects & Warnings - Drugs.com|website=drugs.com}}</ref> Zestoretic,<ref>{{cite web|url=https://www.drugs.com/zestoretic.html|title=Zestoretic: Uses, Dosage & Side Effects - Drugs.com|website=drugs.com}}</ref> and many others. |
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===Fosinopril/hydrochlorothiazide=== |
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==References== |
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{{Drugbox |
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* Drugs.com: |
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<!--Combo data--> |
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* Drugs.com: |
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| drug_name = Fosinopril/hydrochlorothiazide |
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| type = combo |
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| component1 = Fosinopril |
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| class1 = ] |
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| component2 = Hydrochlorothiazide |
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| class2 = ] ] |
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<!--Clinical data--> |
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{{Agents acting on the renin-angiotensin system}} |
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| tradename = Monopril HCT |
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| MedlinePlus = |
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| licence_EU = <!-- EMEA requires brand name --> |
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| licence_US = |
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| pregnancy_AU = |
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| pregnancy_US = |
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| pregnancy_category = C (1st trimester); D (2nd & 3rd trimesters) |
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| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> |
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| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C --> |
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| legal_US = |
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| legal_status = Rx |
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| dependency_liability = |
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| routes_of_administration = ] |
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<!--Identifiers--> |
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] |
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| CAS_number = |
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] |
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| ATC_prefix =C09 |
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| ATC_suffix =BA09 |
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| PubChem = |
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| KEGG = |
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}} |
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]/hydrochlorothiazide (trade name Monopril HCT) has a ] about its risk to cause morbidity and mortality in the baby when being used during pregnancy (second and third trimesters).<ref>{{cite web|title=fosinopril/hydrochlorothiazide (Rx) - Contraindications & Cautions|url=http://reference.medscape.com/drug/fosinopril-hydrochlorothiazide-342334#5|publisher=Medscape|access-date=13 December 2013}}</ref> |
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The FDA modified its labeling in February 2009 to include a precaution of drug interaction with gold. "Nitritoid reactions (symptoms include facial flushing, nausea, vomiting and hypotension) have been reported rarely in patients on therapy with injectable gold (]) and concomitant ACE inhibitor therapy including Monopril/Monopril HCT."<ref>{{cite web|title=Monopril HCT (fosinopril/hydrochlorothiazide) 20/12.5mg and 10/12.5mg Tablets February 2009|url=https://www.fda.gov/Safety/MedWatch/SafetyInformation/Safety-RelatedDrugLabelingChanges/ucm133086.htm|publisher=FDA}}</ref> |
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==See also== |
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*], a combination of an ACE inhibitor and a ] |
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==References== |
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{{reflist}} |
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{{Agents acting on the renin-angiotensin system}} |
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] |
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{{Antihypertensive-stub}} |
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] |
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] |