| Revision as of 11:41, 28 October 2011 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Script assisted update of identifiers for the Chem/Drugbox validation project (updated: 'CASNo').← Previous edit |
Latest revision as of 10:41, 2 January 2024 edit undoArtoria2e5 (talk | contribs)Extended confirmed users, IP block exemptions34,394 edits HONH-Val-Pro-OH |
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{{orphan|date=April 2011}} |
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{{Chembox |
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{{Chembox |
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| Verifiedfields = changed |
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| verifiedrevid = 477241675 |
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| ImageFile = Actinonin.svg |
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| ImageFile = Actinonin.svg |
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| ImageSize = 200px |
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| ImageSize = 200px |
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| IUPACName = (2''R'')-''N''<sup>4</sup>-hydroxy-''N''<sup>1</sup>-{(2''S'')-1--3-methyl-1-oxobutan-2-yl}-2-pentylbutanediamide |
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| PIN = (2''R'')-''N''<sup>4</sup>-Hydroxy-''N''<sup>1</sup>-{(2''S'')-1--3-methyl-1-oxobutan-2-yl}-2-pentylbutanediamide |
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| OtherNames = |
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| OtherNames = HONH-Val-Pro-OH (IUPAC peptide linear) |
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| Section1 = {{Chembox Identifiers |
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|Section1={{Chembox Identifiers |
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| CASNo = <!-- blanked - oldvalue: 13434-13-4 --> |
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| CASNo = 13434-13-4 |
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| CASNo_ref = {{cascite|correct|CAS}} |
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| CASNo_Ref = {{cascite|correct|CAS}} |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| PubChem = 443600 |
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| UNII = P18SPA8N0K |
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| PubChem = 443600 |
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| ChEMBL_Ref = {{ebicite|correct|EBI}} |
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| ChEMBL = 308333 |
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| ChEMBL = 308333 |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID = 391756 |
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| DrugBank = DB04310 |
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| ChemSpiderID = 391756 |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank = DB04310 |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI = 1S/C19H35N3O5/c1-4-5-6-8-14(11-16(24)21-27)18(25)20-17(13(2)3)19(26)22-10-7-9-15(22)12-23/h13-15,17,23,27H,4-12H2,1-3H3,(H,20,25)(H,21,24)/t14-,15+,17+/m1/s1 |
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| StdInChI = 1S/C19H35N3O5/c1-4-5-6-8-14(11-16(24)21-27)18(25)20-17(13(2)3)19(26)22-10-7-9-15(22)12-23/h13-15,17,23,27H,4-12H2,1-3H3,(H,20,25)(H,21,24)/t14-,15+,17+/m1/s1 |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey = XJLATMLVMSFZBN-VYDXJSESSA-N |
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| StdInChIKey = XJLATMLVMSFZBN-VYDXJSESSA-N |
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| SMILES = O=C(N1(CO)CCC1)(NC(=O)(CCCCC)CC(=O)NO)C(C)C |
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| SMILES = O=C(N1(CO)CCC1)(NC(=O)(CCCCC)CC(=O)NO)C(C)C |
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| InChI = InChI=1S/C19H35N3O5/c1-4-5-6-8-14(11-16(24)21-27)18(25)20-17(13(2)3)19(26)22-10-7-9-15(22)12-23/h13-15,17,23,27H,4-12H2,1-3H3,(H,20,25)(H,21,24)/t14-,15+,17+/m1/s1 |
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| InChI = InChI=1S/C19H35N3O5/c1-4-5-6-8-14(11-16(24)21-27)18(25)20-17(13(2)3)19(26)22-10-7-9-15(22)12-23/h13-15,17,23,27H,4-12H2,1-3H3,(H,20,25)(H,21,24)/t14-,15+,17+/m1/s1 |
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}} |
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}} |
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| Section2 = {{Chembox Properties |
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|Section2={{Chembox Properties |
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| C=19 | H=35 | N=3 | O=5 |
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| C=19 | H=35 | N=3 | O=5 |
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| Appearance = |
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| Appearance = |
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| Density = |
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| Density = |
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| MeltingPt = |
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| MeltingPt = |
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| BoilingPt = |
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| BoilingPt = |
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| Solubility = |
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| Solubility = |
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}} |
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}} |
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| Section3 = {{Chembox Hazards |
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|Section3={{Chembox Hazards |
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| MainHazards = |
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| MainHazards = |
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| FlashPt = |
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| FlashPt = |
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| Autoignition = |
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| AutoignitionPt = |
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}} |
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}} |
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}} |
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}} |
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'''Actinonin''' is a naturally occurring ] that has demonstrated ] activity.<ref>{{cite journal | last1 = Chen | first1 = D.Z. | last2 = Patel | first2 = D.V. | title = Actinonin, a Naturally Occurring Antibacterial Agent, Is a Potent Deformylase Inhibitor | journal = Biochemistry | volume = 39 | pages = 1256 | year = 2000 | doi = 10.1021/bi992245y | pmid=10684604}}</ref> |
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'''Actinonin''' is a naturally occurring ] that has demonstrated ] activity.<ref>{{cite journal | last1 = Chen | first1 = D.Z. | last2 = Patel | first2 = D.V. | title = Actinonin, a Naturally Occurring Antibacterial Agent, Is a Potent Deformylase Inhibitor | journal = Biochemistry | volume = 39 | pages = 1256–62 | year = 2000 | doi = 10.1021/bi992245y | pmid=10684604 | issue=6}}</ref> |
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Actiononin has been shown to inhibit the ] ], which is essential in ].<ref>{{Cite journal|last1=Yoon|first1=Hye-Jin|last2=Kim|first2=Hye Lee|last3=Lee|first3=Soo-Kyoung|last4=Kim|first4=Hyun-Woo|last5=Kim|first5=Hyung-Wook|last6=Lee|first6=Jae Young|last7=Mikami|first7=Bunzo|last8=Suh|first8=Se Won|date=2004|title=Crystal structure of peptide deformylase from Staphylococcus aureus in complex with actinonin, a naturally occurring antibacterial agent|url=https://onlinelibrary.wiley.com/doi/abs/10.1002/prot.20231|journal=Proteins: Structure, Function, and Bioinformatics|language=en|volume=57|issue=3|pages=639–642|doi=10.1002/prot.20231|pmid=15382235|s2cid=42929776|issn=1097-0134}}</ref> |
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==References== |
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==References== |
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{{Organic-compound-stub}} |