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Revision as of 15:45, 3 September 2011 editCheMoBot (talk | contribs)Bots141,565 edits Updating {{drugbox}} (no changed fields - added verified revid - updated 'ChemSpiderID_Ref', 'DrugBank_Ref', 'UNII_Ref', 'ChEMBL_Ref', 'ChEBI_Ref', 'KEGG_Ref', 'StdInChI_Ref', 'StdInChIKey_Ref', 'ChEBI_Ref') per [[WP:CHEMVALID|Chem/Drugbox validation← Previous edit Latest revision as of 08:54, 22 December 2024 edit undoWhywhenwhohow (talk | contribs)Autopatrolled, Extended confirmed users, Pending changes reviewers49,153 editsm script-assisted date audit and style fixes per MOS:NUM 
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{{Short description|Pharmaceutical combination}}
{{Drugbox
{{Use dmy dates|date=December 2024}}
⚫ | verifiedrevid = 428689844
{{Infobox drug

| Verifiedfields = changed
⚫ <!--Combo data-->
| Watchedfields = changed
⚫ | verifiedrevid = 448240024
| type = combo | type = combo
| image = Adapalene and benzoyl peroxide.svg
⚫ | width =
| alt =
| caption =

⚫ <!-- Combo data -->
| component1 = Adapalene | component1 = Adapalene
| class1 = ] | class1 = ]
| component2 = Benzoyl peroxide | component2 = Benzoyl peroxide
| class2 = ] | class2 = ]


<!--Clinical data--> <!-- Clinical data -->
| tradename = | tradename = Epiduo, Epiduo Forte
| Drugs.com = {{drugs.com|cons|adapalene-and-benzoyl-peroxide}}
| MedlinePlus =
| DailyMedID = Adapalene and benzoyl peroxide
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_AU_comment =
| pregnancy_US = <!-- A / B / C / D / X -->
| pregnancy_category = | pregnancy_category=
⚫ | routes_of_administration = ]
⚫ | legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
| ATC_prefix = D10
| ATC_suffix = AD53
| ATC_supplemental = {{ATC|D10|AE51}}

<!-- Legal status -->
⚫ | legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled -->
| legal_AU_comment =
| legal_BR = <!-- OTC, A1, A2, A3, B1, B2, C1, C2, C3, C4, C5, D1, D2, E, F -->
| legal_BR_comment =
| legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII --> | legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_CA_comment =
⚫ | legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM -->
| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> | legal_DE = <!-- Anlage I, II, III or Unscheduled -->
| legal_DE_comment =
| legal_NZ = <!-- Class A, B, C -->
| legal_NZ_comment =
⚫ | legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM / Class A, B, C -->
| legal_UK_comment =
| legal_US = Rx-only
| legal_US_comment = <ref name="Epiduo FDA label">{{cite web | title=Epiduo- adapalene and benzoyl peroxide gel | website=DailyMed | date=21 February 2018 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a0610f87-3b39-458a-afa3-66be1fefd1de | access-date=15 May 2022}}</ref><ref name="Epiduo Forte FDA label">{{cite web | title=Epiduo Forte- adapalene and benzoyl peroxide gel | website=DailyMed | date=27 April 2022 | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f4e5d381-098a-4c93-9ff0-002cae46daac | access-date=15 May 2022}}</ref>
| legal_EU =
| legal_EU_comment =
| legal_UN = <!-- N I, II, III, IV / P I, II, III, IV -->
| legal_UN_comment =
| legal_status = Rx-only | legal_status = Rx-only
⚫ | routes_of_administration = Epicutaneous


<!--Identifiers--> <!-- Identifiers -->
| CAS_number_Ref = {{cascite|changed|??}}
| CAS_number = | CAS_number = 1194805-81-6
⚫ | ATCvet =
| CAS_supplemental =
| ATC_prefix = <!-- 'none' if uncategorised -->
| ATC_suffix = | PubChem =
| PubChem = | IUPHAR_ligand =
| DrugBank =
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = | ChemSpiderID =
| UNII =

| KEGG_Ref = {{keggcite|changed|kegg}}
<!--Chemical data-->
| KEGG = D10792
| ChEBI =
| ChEMBL =
| synonyms =
}} }}
''']/]''' is a ] combination for the treatment of ], marketed by ] under the trade name '''Epiduo'''.<ref name="webmdann">http://www.webmd.com/skin-problems-and-treatments/acne/news/20090106/fda-oks-new-acne-gel-epiduo</ref> It consists of a combination of adapalene (0.1%) and benzoyl peroxide (2.5%) in a topical ].<ref name="webmdann"/>


'''Adapalene/benzoyl peroxide''', sold under the brand name '''Epiduo''' among others, is a ] medication for the treatment of ].<ref name="Epiduo FDA label" /><ref name="Epiduo Forte FDA label" /> It is a combination of ], a retinoid; and ].<ref name="Epiduo FDA label" /><ref name="Epiduo Forte FDA label" />
==Interactions==

Patients are advised to exercise caution in using Epiduo together with other skin products containing ], ], or ], or with medicated or abrasive ]s and ]s.<ref name="prescribe"/> Skin products with high levels of ] or ]s should also be avoided.<ref name="prescribe"/> Using topical products with a strong drying effect in combination with Epiduo can increase irritation.<ref name="prescribe"/>
It is available as a ].<ref>{{cite web | title=Competitive Generic Therapy Approvals | website=U.S. ] (FDA) | date=29 June 2023 | url=https://www.fda.gov/drugs/generic-drugs/competitive-generic-therapy-approvals | access-date=29 June 2023 | archive-date=29 June 2023 | archive-url=https://web.archive.org/web/20230629233651/https://www.fda.gov/drugs/generic-drugs/competitive-generic-therapy-approvals | url-status=live }}</ref> In 2022, it was the 292nd most commonly prescribed medication in the United States, with more than 400,000 prescriptions.<ref name="Top 300 of 2022">{{cite web | title=The Top 300 of 2022 | url=https://clincalc.com/DrugStats/Top300Drugs.aspx | website=ClinCalc | access-date=30 August 2024 | archive-date=30 August 2024 | archive-url=https://web.archive.org/web/20240830202410/https://clincalc.com/DrugStats/Top300Drugs.aspx | url-status=live }}</ref><ref>{{cite web | title = Adapalene; Benzoyl Peroxide Drug Usage Statistics, United States, 2013 - 2022 | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/AdapaleneBenzoylPeroxide | access-date = 30 August 2024 }}</ref>

== Medical uses ==
Adapalene/benzoyl peroxide is ] for the ] of acne vulgaris.<ref name="Epiduo FDA label" /><ref name="Epiduo Forte FDA label" />


==Side effects== ==Side effects==
Commonly reported side effects include:<ref name="prescribe"></ref> Commonly reported side effects include the following:<ref name="Epiduo FDA label" /><ref name="Epiduo Forte FDA label" />
* ] * ]
* ] * ]
* ] * ]
* ] * ]
* ] ] * ] ]
* ] * ]
* ] * ]


==Precautions== == Research ==
Meta-analysis of clinical trials has shown this combined therapy to be more effective than either of its ingredients by themselves.<ref>{{cite journal | vauthors = Tan J, Gollnick HP, Loesche C, Ma YM, Gold LS | title = Synergistic efficacy of adapalene 0.1%-benzoyl peroxide 2.5% in the treatment of 3855 acne vulgaris patients | journal = The Journal of Dermatological Treatment | volume = 22 | issue = 4 | pages = 197–205 | date = August 2011 | pmid = 20666678 | doi = 10.3109/09546631003681094 | s2cid = 34631151 }}</ref>
Patients are advised to avoid exposure to ] and ], and use ] when these cannot be avoided.<ref name="prescribe"/>


The use of adapalene/benzoyl peroxide in combination with oral antibiotics (]) has been studied;<ref>{{cite journal | vauthors = Dréno B, Kaufmann R, Talarico S, Torres Lozada V, Rodríguez-Castellanos MA, Gómez-Flores M, De Maubeuge J, Berg M, Foley P, Sysa-Jedrzejowska A, Kerrouche N, Paliargues F, Bettoli V | display-authors = 6 | title = Combination therapy with adapalene-benzoyl peroxide and oral lymecycline in the treatment of moderate to severe acne vulgaris: a multicentre, randomized, double-blind controlled study | journal = The British Journal of Dermatology | volume = 165 | issue = 2 | pages = 383–90 | date = August 2011 | pmid = 21495995 | doi = 10.1111/j.1365-2133.2011.10374.x | s2cid = 21793660 }}</ref> the combination was well tolerated and showed an improved success rate compared to those receiving only antibiotics (47.6% vs. 33.7%, P = 0.002).
==References==
<references/>


==External links== == References ==
{{reflist}}
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{{Nestlé}}
{{Acne Agents}} {{Acne Agents}}
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{{DEFAULTSORT:Adapalene Benzoyl Peroxide}}

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