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{{Short description|Chemical compound}} |
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{{Unreferenced|date=November 2009}} |
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{{drugbox |
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{{Drugbox |
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| verifiedrevid = 437205813 |
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| Verifiedfields = changed |
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| IUPAC_name = 7-Chloro-3-quinazolin-4-one |
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| UNII_Ref = {{fdacite|changed|FDA}} |
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| image = Albaconazole.svg |
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| UNII = YDW24Y8IAB |
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| verifiedrevid = 413307952 |
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<!--Clinical data--> |
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| IUPAC_name = 7-chloro-3-quinazolin-4-one |
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| tradename = |
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| image = Albaconazole.svg |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| pregnancy_US = <!-- A / B / C / D / X --> |
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| pregnancy_category = |
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| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> |
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| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C --> |
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| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> |
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| legal_status = |
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| routes_of_administration = |
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<!--Pharmacokinetic data--> |
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| bioavailability = |
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| protein_bound = |
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| metabolism = |
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| elimination_half-life = |
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| excretion = |
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<!--Identifiers--> |
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| CAS_number_Ref = {{cascite|correct|??}} |
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| CAS_number = 187949-02-6 |
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| ATC_prefix = none |
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| ATC_suffix = |
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| ATC_supplemental = |
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| PubChem = 208952 |
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| DrugBank_Ref = {{drugbankcite|correct|drugbank}} |
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| DrugBank = |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID = 181045 |
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| ChemSpiderID = 181045 |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| InChI = 1/C20H16ClF2N5O2/c1-12(28-11-25-18-6-13(21)2-4-15(18)19(28)29)20(30,8-27-10-24-9-26-27)16-5-3-14(22)7-17(16)23/h2-7,9-12,30H,8H2,1H3/t12-,20-/m1/s1 |
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| UNII = YDW24Y8IAB |
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| InChIKey = UHIXWHUVLCAJQL-MPBGBICIBS |
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| KEGG_Ref = {{keggcite|correct|kegg}} |
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| smiles = Fc1ccc(c(F)c1)(O)((N3\C=N/c2cc(Cl)ccc2C3=O)C)Cn4ncnc4 |
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| KEGG = D09702 |
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| ChEMBL_Ref = {{ebicite|correct|EBI}} |
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| ChEMBL_Ref = {{ebicite|correct|EBI}} |
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| ChEMBL = 298817 |
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| ChEMBL = 298817 |
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<!--Chemical data--> |
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| chemical_formula = |
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| C=20 | H=16 | Cl=1 | F=2 | N=5 | O=2 |
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| smiles = Fc1ccc(c(F)c1)(O)((N3\C=N/c2cc(Cl)ccc2C3=O)C)Cn4ncnc4 |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI = 1S/C20H16ClF2N5O2/c1-12(28-11-25-18-6-13(21)2-4-15(18)19(28)29)20(30,8-27-10-24-9-26-27)16-5-3-14(22)7-17(16)23/h2-7,9-12,30H,8H2,1H3/t12-,20-/m1/s1 |
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| StdInChI = 1S/C20H16ClF2N5O2/c1-12(28-11-25-18-6-13(21)2-4-15(18)19(28)29)20(30,8-27-10-24-9-26-27)16-5-3-14(22)7-17(16)23/h2-7,9-12,30H,8H2,1H3/t12-,20-/m1/s1 |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey = UHIXWHUVLCAJQL-MPBGBICISA-N |
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| StdInChIKey = UHIXWHUVLCAJQL-MPBGBICISA-N |
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| CAS_number = 187949-02-6 |
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| CAS_supplemental = |
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| ATC_prefix = none |
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| ATC_suffix = |
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| ATC_supplemental = |
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| PubChem = 208952 |
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| DrugBank = |
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| KEGG_Ref = {{keggcite|correct|kegg}} |
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| KEGG = D09702 |
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| chemical_formula = |
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| C=20 | H=16 | Cl=1 | F=2 | N=5 | O=2 |
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| molecular_weight = 431.823146 g/mol |
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| bioavailability = |
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| protein_bound = |
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| metabolism = |
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| elimination_half-life = |
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| excretion = |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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| ⚫ |
| pregnancy_US = <!-- A / B / C / D / X --> |
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| pregnancy_category= |
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| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled--> |
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| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII --> |
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| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C --> |
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| legal_US = <!-- OTC / Rx-only / Schedule I, II, III, IV, V --> |
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| legal_status = |
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| routes_of_administration = |
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}} |
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}} |
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'''Albaconazole (UR-9825)''' is a ] antifungal. It has potential broad-spectrum activity. |
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'''Albaconazole''' (development code '''UR-9825''') is an experimental ] antifungal.<ref>{{cite web | url = https://adisinsight.springer.com/drugs/800009452 | title = Albaconazole | work = Adis Insight | publisher = Springer Nature Switzerland AG }}</ref> It has potential broad-spectrum activity. The drug blocks a number of ] liver enzymes.{{cn|date=December 2022}} |
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It has also been studied as an ] agent.<ref>{{cite journal | vauthors = Guedes PM, Urbina JA, de Lana M, Afonso LC, Veloso VM, Tafuri WL, Machado-Coelho GL, Chiari E, Bahia MT | display-authors = 6 | title = Activity of the new triazole derivative albaconazole against Trypanosoma (Schizotrypanum) cruzi in dog hosts | journal = Antimicrobial Agents and Chemotherapy | volume = 48 | issue = 11 | pages = 4286–92 | date = November 2004 | pmid = 15504854 | pmc = 525424 | doi = 10.1128/AAC.48.11.4286-4292.2004 }}</ref> |
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== References == |
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{{Reflist}} |
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{{Antifungals}} |
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{{antiinfective-agent-stub}} |
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{{antiinfective-agent-stub}} |