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{{chembox |
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{{chembox |
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| verifiedrevid = 399529379 |
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| verifiedrevid = 441877939 |
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|ImageFile=Aphidicolin structure.png |
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| ImageFile=Aphidicolin structure.png |
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|ImageSize=200px |
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| ImageSize=200px |
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|IUPACName= (3''R'',4''R'',4a''R'',6a''S'',8''R'',9''R'',11a''S'',11b''S'')-4,9-bis(hydroxymethyl)-4,11b-dimethyltetradecahydro-8,11a-methanocycloheptanaphthalene-3,9-diol |
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| IUPACName= (3''R'',4''R'',4a''R'',6a''S'',8''R'',9''R'',11a''S'',11b''S'')-4,9-bis(hydroxymethyl)-4,11b-dimethyltetradecahydro-8,11a-methanocycloheptanaphthalene-3,9-diol |
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|OtherNames= |
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| OtherNames= |
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|Section1={{Chembox Identifiers |
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|Section1={{Chembox Identifiers |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| ChemSpiderID = 10280269 |
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| ChemSpiderID = 10280269 |
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| ChEMBL_Ref = {{ebicite|changed|EBI}} |
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| ChEBI_Ref = {{ebicite|changed|EBI}} |
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| ChEBI = 2766 |
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| ChEMBL_Ref = {{ebicite|correct|EBI}} |
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| ChEMBL = 29711 |
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| ChEMBL = 29711 |
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| InChI = 1/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1 |
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| InChI = 1/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1 |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey = NOFOAYPPHIUXJR-APNQCZIXSA-N |
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| StdInChIKey = NOFOAYPPHIUXJR-APNQCZIXSA-N |
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| CASNo_Ref = {{cascite|correct|??}} |
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| CASNo=38966-21-1 |
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| CASNo=38966-21-1 |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| PubChem=457964 |
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| UNII = 192TJ6PP19 |
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| SMILES = OC4(O)CC31C4C3CC2(C)(CO)(O)CC12C |
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| PubChem=457964 |
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| SMILES = OC4(O)CC31C4C3CC2(C)(CO)(O)CC12C |
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|Section2={{Chembox Properties |
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|Section2={{Chembox Properties |
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|C=20|H=34|O=4 |
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| C=20 | H=34 | O=4 |
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| MolarMass=338.48 g/mol |
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| MolarMass=338.48 g/mol |
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|Section3={{Chembox Hazards |
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|Section3={{Chembox Hazards |
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| AutoignitionPt = |
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'''Aphidicolin''' is defined as a tetracyclic ] ] with antiviral and antimitotical properties. Aphidicolin is a reversible ] of ] nuclear ] replication. It blocks the cell cycle at early ]. It is a specific inhibitor of ] B,D in eukaryotic cells and in some viruses and an ] inducer in ] cells. |
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'''Aphidicolin''' is a tetracyclic ] ] isolated from the fungus '']'' with antiviral and antimitotic properties. Aphidicolin is a reversible ] of ] nuclear ] replication. It blocks the cell cycle at early ]. It is a specific inhibitor of ] and ] in eukaryotic cells and in some viruses (]<ref>{{cite journal|last1=DeFilippes|first1=FM|title=Effect of aphidicolin on vaccinia virus: isolation of an aphidicolin-resistant mutant.|journal=Journal of Virology|date=Nov 1984|volume=52|issue=2|pages=474–82|doi=10.1128/JVI.52.2.474-482.1984|pmid=6436508|pmc=254548}}</ref><ref>{{cite journal|last1=Bucknall|first1=R. A.|last2=Moores|first2=H.|last3=Simms|first3=R.|last4=Hesp|first4=B.|title=Antiviral Effects of Aphidicolin, a New Antibiotic Produced by Cephalosporium aphidicola|journal=Antimicrobial Agents and Chemotherapy|date=1 September 1973|volume=4|issue=3|pages=294–298|doi=10.1128/AAC.4.3.294|pmc=444544|pmid=4357181}}</ref> and ]) and an ] inducer in ] cells. Natural aphidicolin is a secondary metabolite of the fungus '']''.<ref> {{webarchive |url=https://web.archive.org/web/20060626051436/http://www.fermentek.co.il/aphidicolin.htm |date=June 26, 2006 }} from ]</ref> |
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<br>Natural aphidicolin is a secondary metabolite of the fungus '']''<ref> from ]</ref>. |
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==References== |
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== Bibliography == |
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* {{cite journal |author=Dhillon VS, Husain SA, Ray GN |title=Expression of aphidicolin-induced fragile sites and their relationship between genetic susceptibility in breast cancer, ovarian cancer, and non-small-cell lung cancer patients |journal=Teratog., Carcinog. Mutagen. |volume=Suppl 1 |issue= |pages=35–45 |year=2003 |pmid=12616595 |doi=10.1002/tcm.10068 |url=}} |
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* {{cite journal |vauthors=Dhillon VS, Husain SA, Ray GN |title=Expression of aphidicolin-induced fragile sites and their relationship between genetic susceptibility in breast cancer, ovarian cancer, and non-small-cell lung cancer patients |journal=Teratogenesis, Carcinogenesis, and Mutagenesis |volume=Suppl 1 |pages=35–45 |year=2003 |pmid=12616595 |doi=10.1002/tcm.10068 }} |
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* {{cite book|last1=Mahy|first1=Brian W J|title=A dictionary of virology|url=https://archive.org/details/dictionaryofviro0000mahy|url-access=registration|date=2001|publisher=Academic Press|location=San Diego, Calif. |isbn=978-0-12-465327-6|page=|edition=3.}} |
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== References == |
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