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Revision as of 13:11, 28 October 2011 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Script assisted update of identifiers for the Chem/Drugbox validation project (updated: 'CASNo').← Previous edit Latest revision as of 05:52, 2 January 2025 edit undoArthurfragoso (talk | contribs)Extended confirmed users2,003 edits Fixes image in dark mode 
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{{Unreferenced|date=December 2009}}
{{Chembox {{Chembox
| Verifiedfields = changed
⚫ |ImageFile=Argininosuccinic acid.svg
| Watchedfields = changed
⚫ |ImageSize=200px
| verifiedrevid = 457813295
⚫ |IUPACName=''N''-amino}(imino)methyl]-<small>L</small>-aspartic acid
⚫ | ImageFile=Argininosuccinic acid.svg
⚫ |OtherNames=
| ImageClass = skin-invert
⚫ |Section1= {{Chembox Identifiers
⚫ | ImageSize=200px
⚫ | ChemSpiderID = 16059
⚫ | IUPACName=''N''-amino}(imino)methyl]-<small>L</small>-aspartic acid
⚫ | OtherNames=
⚫ |Section1={{Chembox Identifiers
| IUPHAR_ligand = 5324
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
⚫ | ChemSpiderID = 16059
| InChI = 1/C10H18N4O6/c11-5(8(17)18)2-1-3-13-10(12)14-6(9(19)20)4-7(15)16/h5-6H,1-4,11H2,(H,15,16)(H,17,18)(H,19,20)(H3,12,13,14)/t5-,6-/m0/s1 | InChI = 1/C10H18N4O6/c11-5(8(17)18)2-1-3-13-10(12)14-6(9(19)20)4-7(15)16/h5-6H,1-4,11H2,(H,15,16)(H,17,18)(H,19,20)(H3,12,13,14)/t5-,6-/m0/s1
| InChIKey = KDZOASGQNOPSCU-WDSKDSINBJ | InChIKey = KDZOASGQNOPSCU-WDSKDSINBJ
| CASNo_Ref = {{cascite|changed|??}}
| CASNo = <!-- blanked - oldvalue: 2387-71-5 -->
| CASNo=2387-71-5
⚫ | StdInChI = 1S/C10H18N4O6/c11-5(8(17)18)2-1-3-13-10(12)14-6(9(19)20)4-7(15)16/h5-6H,1-4,11H2,(H,15,16)(H,17,18)(H,19,20)(H3,12,13,14)/t5-,6-/m0/s1
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = T67NZ5MU4H
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
⚫ | StdInChI = 1S/C10H18N4O6/c11-5(8(17)18)2-1-3-13-10(12)14-6(9(19)20)4-7(15)16/h5-6H,1-4,11H2,(H,15,16)(H,17,18)(H,19,20)(H3,12,13,14)/t5-,6-/m0/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = KDZOASGQNOPSCU-WDSKDSINSA-N | StdInChIKey = KDZOASGQNOPSCU-WDSKDSINSA-N
| PubChem=16950 | PubChem=16950
| SMILES = O=C(O)C(C(=O)O)NC(=N/CCC(N)C(=O)O)/N | SMILES = O=C(O)C(C(=O)O)NC(=N/CCC(N)C(=O)O)/N
}} }}
|Section2= {{Chembox Properties |Section2={{Chembox Properties
| C=10|H=18|N=4|O=6 | C=10 | H=18 | N=4 | O=6
| MolarMass=290.27312 | MolarMass=290.27312
| Appearance= | Appearance=
| Density= | Density=
| MeltingPt= | MeltingPt=
| BoilingPt= | BoilingPt=
| Solubility= | Solubility=
}} }}
|Section3= {{Chembox Hazards |Section3={{Chembox Hazards
| MainHazards= | MainHazards=
| FlashPt= | FlashPt=
| AutoignitionPt =
| Autoignition=
}} }}
}} }}


'''Argininosuccinic acid''' is a ] that is an important intermediate in the ]. <ref>{{Cite journal |last1=Ganetzky |first1=Rebecca D. |last2=Bedoukian |first2=Emma |last3=Deardorff |first3=Matthew A. |last4=Ficicioglu |first4=Can |date=2017 |title=Argininosuccinic Acid Lyase Deficiency Missed by Newborn Screen |journal=JIMD Reports |volume=34 |pages=43–47 |doi=10.1007/8904_2016_2 |issn=2192-8304 |pmc=5509549 |pmid=27515243|isbn=978-3-662-55585-9 }}</ref> It is also known as '''argininosuccinate'''.<ref>{{Cite web |last=PubChem |title=Argininosuccinate |url=https://pubchem.ncbi.nlm.nih.gov/compound/828 |access-date=2023-01-01 |website=pubchem.ncbi.nlm.nih.gov |language=en}}</ref>
'''Argininosuccinic acid''' is a ] that is a ] ].


==Reactions== ==Reactions==
Some cells synthesize argininosuccinic acid from ] and ] and use it as a precursor for ] in the ] (or ]), releasing ] as a by-product to enter the ]. The enzyme that catalyzes the reaction is ].<ref>{{Cite journal |last1=González-Noriega |first1=A. |last2=Verduzco |first2=J. |last3=Prieto |first3=E. |last4=Velázquez |first4=A. |date=1980 |title=Argininosuccinic acid synthetase deficiency in a hamster cell line and its complementation of argininosuccinic aciduria human fibroblasts |url=https://pubmed.ncbi.nlm.nih.gov/6777600/ |journal=Journal of Inherited Metabolic Disease |volume=3 |issue=2 |pages=45–48 |doi=10.1007/BF02312521 |issn=0141-8955 |pmid=6777600|s2cid=27912636 }}</ref><ref>{{Cite journal |last1=Nakata |first1=M. |last2=Yada |first2=T. |last3=Nakagawa |first3=S. |last4=Kobayashi |first4=K. |last5=Maruyama |first5=I. |date=1997-06-27 |title=Citrulline-argininosuccinate-arginine cycle coupled to Ca2+-signaling in rat pancreatic beta-cells |url=https://pubmed.ncbi.nlm.nih.gov/9207208/ |journal=Biochemical and Biophysical Research Communications |volume=235 |issue=3 |pages=619–624 |doi=10.1006/bbrc.1997.6854 |issn=0006-291X |pmid=9207208}}</ref>
Some cells synthesize argininosuccinic acid from ] and ] and use it as a precursor for ] in the ] or ]. The enzyme that catalyzes the reaction is ].


Argininosuccinic acid is a precursor to ] in the ] via ].<ref>{{Citation |last1=Nagamani |first1=Sandesh C. Sreenath |title=Argininosuccinate Lyase Deficiency |date=1993 |url=http://www.ncbi.nlm.nih.gov/books/NBK51784/ |work=GeneReviews® |editor-last=Adam |editor-first=Margaret P. |place=Seattle (WA) |publisher=University of Washington, Seattle |pmid=21290785 |access-date=2023-01-01 |last2=Erez |first2=Ayelet |last3=Lee |first3=Brendan |editor2-last=Everman |editor2-first=David B. |editor3-last=Mirzaa |editor3-first=Ghayda M. |editor4-last=Pagon |editor4-first=Roberta A.}}</ref>
Argininosuccinic acid is a precursor to ] in the ] via ].


==See also== ==See also==
* ] * ]


== References ==
{{Urea cycle}} <references />{{Urea cycle}}


{{DEFAULTSORT:Argininosuccinic Acid}} {{DEFAULTSORT:Argininosuccinic Acid}}
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