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Revision as of 14:54, 13 November 2010 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Script assisted update of identifiers from ChemSpider, CommonChemistry and FDA for the Chem/Drugbox validation project - Updated: StdInChI StdInChIKey.← Previous edit Latest revision as of 00:11, 5 November 2022 edit undoEntranced98 (talk | contribs)Extended confirmed users, Pending changes reviewers, Rollbackers172,083 edits +sd 
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{{short description|Chemical compound}}
{{Drugbox {{Drugbox
| verifiedrevid = 396516252
| IUPAC_name = 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathiine 10,10-dioxide | IUPAC_name = 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathiine 10,10-dioxide
| image = CX157 structure.svg | image = CX157 structure.svg

<!--Clinical data-->
| tradename =
| pregnancy_category =
| legal_status = Uncontrolled
| routes_of_administration = Oral

<!--Pharmacokinetic data-->
| bioavailability =
| metabolism =
| elimination_half-life =
| excretion =

<!--Identifiers-->
| CAS_number = 205187-53-7
| CAS_number_Ref = {{cascite|correct|CAS}}
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = O6L62LZJ0Q
| ATC_prefix = none
| ATC_suffix =
| PubChem = 18687754
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 13701383

<!--Chemical data-->
| C = 14 | H = 8 | F = 4 | O = 4 | S = 1
| smiles = FC(F)(F)COc2cc3Oc1cc(F)ccc1S(=O)(=O)c3cc2
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C14H8F4O4S/c15-8-1-3-12-10(5-8)22-11-6-9(21-7-14(16,17)18)2-4-13(11)23(12,19)20/h1-6H,7H2 | StdInChI = 1S/C14H8F4O4S/c15-8-1-3-12-10(5-8)22-11-6-9(21-7-14(16,17)18)2-4-13(11)23(12,19)20/h1-6H,7H2
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = PDIMOTRDGUQMNY-UHFFFAOYSA-N | StdInChIKey = PDIMOTRDGUQMNY-UHFFFAOYSA-N
| CAS_number =
| ATC_prefix = none
| ATC_suffix =
| PubChem = 18687754
| ChemSpiderID = 13701383
| chemical_formula = C<sub>14</sub>H<sub>8</sub>F<sub>4</sub>O<sub>4</sub>S
| molecular_weight = 348.27 g/mol
| smiles = FC(F)(F)COc2cc3Oc1cc(F)ccc1S(=O)(=O)c3cc2
| bioavailability =
| metabolism =
| elimination_half-life =
| excretion =
| pregnancy_category =
| legal_status = Uncontrolled
| routes_of_administration = Oral
}} }}


'''Tyrima''' ('''CX157''') is a ] and ] (RIMA).<ref>{{cite conference |author=Fielding R, Mielach F, Free J, Pande A |title=Pharmacokinetics and oral bioavailability of CX157, a reversible selective MAO-A inhibitor, in primates |year=2007 |conference=2007 AAPS Annual Meeting & Exposition |url=http://www.aapsj.org/abstracts/AM_2007/AAPS2007-001233.PDF |accessdate=2009-06-14}}</ref> It is currently in phase II ]s for the treatment of ].<ref>{{ClinicalTrialsGov|NCT00739908}}</ref> '''CX157''' (proposed trade name '''TriRima''', formerly '''Tyrima''') is a ] and ] (RIMA).<ref>{{cite conference |vauthors=Fielding R, Mielach F, Free J, Pande A |title=Pharmacokinetics and oral bioavailability of CX157, a reversible selective MAO-A inhibitor, in primates |year=2007 |conference=2007 AAPS Annual Meeting & Exposition |url=http://www.aapsj.org/abstracts/AM_2007/AAPS2007-001233.PDF |accessdate=2009-06-14 |archive-url=https://web.archive.org/web/20110526192425/http://www.aapsj.org/abstracts/AM_2007/AAPS2007-001233.PDF |archive-date=2011-05-26 |url-status=dead }}</ref> As of 2007 it was in ] ]s for the treatment of ].<ref>{{ClinicalTrialsGov|NCT00739908}|A Study of CX157 (TriRima) for the Treatment of Depression (CX157-200)}}</ref> In 2013, work on the drug was terminated.

== See also ==
* ] (RIMA)
* ] (MAOI)


== References == ==References==
{{Reflist|2}} {{Reflist|2}}




{{Monoamine metabolism modulators}}
{{Antidepressants}}
{{Anxiolytics}}
{{Adrenergics}}
{{Dopaminergics}}
{{Serotonergics}}


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]