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Revision as of 17:08, 10 November 2011 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Script assisted update of identifiers for the Chem/Drugbox validation project (updated: 'ChemSpiderID', 'StdInChI', 'StdInChIKey', 'CASNo').← Previous edit Latest revision as of 07:39, 24 June 2022 edit undoCewbot (talk | contribs)Bots7,156,205 editsm Normalize {{Multiple issues}}: Create {{Multiple issues}} with 3 maintenance templates: More citations needed, Notability, Fringe theories 
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{{Multiple issues|
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{{chembox {{chembox
| Verifiedfields = changed
| verifiedrevid = 416053615 | verifiedrevid = 459993174
|ImageFile=Calcium 2-amino ethyl phosphoric acid.png | ImageFile=Calcium 2-amino ethyl phosphoric acid.png
|ImageSize=200px | ImageSize=200px
|IUPACName=Calcium 2-aminoethyl phosphate | PIN=Calcium 2-aminoethyl phosphate
|OtherNames= | OtherNames=
|Section1={{Chembox Identifiers |Section1={{Chembox Identifiers
| CASNo_Ref = {{cascite|changed|??}}
| CASNo = <!-- blanked - oldvalue: 10389-08-9 -->
| CASNo=10389-08-9
⚫ | ChemSpiderID = 14508512

| UNII_Ref = {{fdacite|changed|FDA}}
| UNII = Y68G4M097Y


| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
⚫ | ChemSpiderID = 14508512
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C2H8NO4P.Ca/c3-1-2-7-8(4,5)6;/h1-3H2,(H2,4,5,6);/q;+2/p-2 | StdInChI = 1S/C2H8NO4P.Ca/c3-1-2-7-8(4,5)6;/h1-3H2,(H2,4,5,6);/q;+2/p-2
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = SYLKQIHLJRQWAY-UHFFFAOYSA-L | StdInChIKey = SYLKQIHLJRQWAY-UHFFFAOYSA-L
| PubChem=19985431 | PubChem=19985431
| SMILES=C(COP(=O)())N. | SMILES=C(COP(=O)())N.
}} }}
|Section2={{Chembox Properties |Section2={{Chembox Properties
| Formula=C<sub>2</sub>H<sub>6</sub>CaNO<sub>4</sub>P | Formula=C<sub>2</sub>H<sub>6</sub>CaNO<sub>4</sub>P
| MolarMass=179.13 g/mol | MolarMass=179.13 g/mol
| Appearance= | Appearance=
| Density= | Density=
| MeltingPt= | MeltingPt=
| BoilingPt= | BoilingPt=
| Solubility= | Solubility=
}} }}
|Section3={{Chembox Hazards |Section3={{Chembox Hazards
| MainHazards= | MainHazards=
| FlashPt= | FlashPt=
| AutoignitionPt =
| Autoignition=
}} }}
}} }}


'''Calcium 2-aminoethylphosphate''' (Ca-AEP or Ca-2AEP) is a vital component in the structure of cell membranes in the human body. It is the ] ] of ]. It was discovered by the eminent biochemist ] in 1941. Ca-AEP has been shown to help maintain cell membrane integrity and improve cellular functions. It was patented by Dr. ] and Franz Kohler '''Calcium 2-aminoethylphosphate''' ('''Ca-AEP''' or '''Ca-2AEP''') is a compound discovered by the biochemist ] in 1941.{{Citation needed|date=June 2022}} It is the ] ] of ]. It was patented by ] and Franz Kohler.{{Citation needed|date=June 2022}}


==Terminology and glossary== ==Terminology and glossary==
Calcium 2-amino ethyl phosphoric acid (Ca-AEP or Ca-2AEP) is also called calcium ethylamino-phosphate (calcium EAP), calcium colamine phosphate, calcium 2-aminoethyl ester of phosphoric acid, and calcium 2-amino ethanol phosphate Calcium 2-amino ethyl phosphoric acid (Ca-AEP or Ca-2AEP) is also called calcium ethylamino-phosphate (calcium EAP), calcium colamine phosphate, calcium 2-aminoethyl ester of phosphoric acid, and calcium 2-amino ethanol phosphate


2-AEP plays a role as a component in the cell membrane and at the same time has the property to form complexes with minerals. This mineral transporter goes into the outer layer of the outer cell membrane where it releases its associated mineral and is itself metabolized with the structure of the cell membrane.{{Clarify|date=February 2009}} The effect here is an increase of the electrical condenser function of cell membranes to resist toxins and viruses which may otherwise enter the cell and cause cellular degeneration.{{Citation needed|date=August 2008}} Calcium 2-AEP is said to be effective for repairing cell membrane damage.{{Citation needed|date=August 2008}} In Germany, calcium, potassium and magnesium 2-AEP are officially declared as the only active substances for the treatment of multiple sclerosis.{{Citation needed|date=August 2008}} 2-AEP plays a role as a component in the cell membrane and at the same time has the property to form complexes with minerals. This mineral transporter goes into the outer layer of the outer cell membrane where it releases its associated mineral and is itself metabolized with the structure of the cell membrane.{{Clarify|date=February 2009}}{{Citation needed|date=June 2022}}


==History, treatments, uses, and risks== ==History, treatments, uses, and risks==
Ca-AEP was discovered by ] in 1953.{{Citation needed|date=June 2022}}
CA-AEP was discovered by Erwin Chargaff, best known for his work that eventually led to the discovery of the double helix structure of ], in 1941. His findings were largely ignored for the first two decades but studies over the last 30 years have shown that Ca-AEP plays a vital role in maintaining cell membrane integrity and improving cellular functions.{{Citation needed|date=August 2008}} People have been using this to treat a host of ailments including multiple sclerosis, diabetes, asthma and immune disorders.

The first trial applications of Ca-AEP were for the treatment of ] (MS).{{Citation needed|date=August 2008}} In 1967 the German Health Authority approved the use of Ca-AEP for MS. MS, an inflammatory demyelinating condition, is one of the most common diseases of the central nervous system (brain and spinal cord). ], the fatty material that surrounds nerves, acts as an insulator, much like the covering of an electric wire. An analysis of more than 2,000 patients who were treated with colamine salts in Germany over the course of 24 years revealed greater efficacy from Ca-AEP treatments than other known treatments.{{Citation needed|date=August 2008}} In 1986, Dr. George Morrissette conducted a retrospective poll of patients in the USA who originally had begun Ca-AEP treatment in Germany for MS. 82% of the almost 300 patients that entered the study showed a positive benefit from Ca-AEP therapy. And when treatment began in the early stages of MS, positive results rose to 92%.{{Citation needed|date=August 2008}}

After 30 years of Ca-AEP and calcium orotate therapies with over 3,500 patients with multiple sclerosis, the risk of bone fractures was drastically reduced.{{Citation needed|date=August 2008}} Furthermore, surgeons in six surgical centers located in USA and Europe reported finding extremely solid bone when implanting new joints in patients who were taking Ca-AEP combined with calcium and magnesium orotate for at least four years prior to their surgeries.{{Citation needed|date=August 2008}}

In 1967, the German Health Authority approved calcium 2-AEP as an official treatment for multiple sclerosis. In fact, 2-AEP is the only natural official MS treatment reimbursed by the German equivalent of the US Social Security System.{{Citation needed|date=August 2008}}


According to the U.S. ] Calcium EAP is often promoted as a cure or therapy for Multiple Sclerosis and many other diseases. However, it states that it is not recommended by its medical advisory board, and also notes that the ] has classified it as unsafe and unapproved for use.<ref>{{Cite web |date=2006 |title=Calcium EAP (Calcium Orotate) |url=https://secure.nationalmssociety.org/docs/HOM/calciumEAP.pdf |website=National MS Society Information Sourcebook}}</ref>
The U.S. ] states that “calcium EAP protocol is not recommended by the Medical Advisory Board of the National MS Society.”{{Citation needed|date=August 2008}} The National MS Society warns of side effects and risk, but they do not list any on their website for this treatment. They do state that it “may include a powerful drug that suppresses the immune system” but they do not mention what this drug is.<!--This statement appears to be out of context-->


Calcium 2-AEP is actually manufactured by numerous ] companies and is sold online and in ]s. Calcium 2-AEP is manufactured by numerous ] companies and is sold online and in ]s.


==References== ==References==
<references/>
* , Ward Dean, M.D. and Jim English (June 1999)
* Hans Nieper, M.D. (1992) Reproduced by the Brewer Science Library with permission from Let's Live magazine
* , National MS Society (Feb 2006)


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==External links==
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