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Revision as of 19:29, 7 August 2011 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Script assisted update of identifiers for the Chem/Drugbox validation project (updated: 'ChEBI').← Previous edit Latest revision as of 14:32, 25 November 2024 edit undoM97uzivatel (talk | contribs)Extended confirmed users6,558 edits added Category:Thioethers using HotCat 
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{{chembox {{chembox
| Verifiedfields = changed
| verifiedrevid = 414094014
| Watchedfields = changed
| verifiedrevid = 443553935
| ImageFile_Ref = {{chemboximage|correct|??}} | ImageFile_Ref = {{chemboximage|correct|??}}
| ImageFile=Cystathionine.png | ImageFile = Cystathionin.svg
| ImageSize = 220
|ImageName=Skeletal formula
| ImageAlt = Skeletal formula of cystathionine
|ImageFile1=Cystathionine-3D-balls.png | ImageFile1 = Cystathionine zwitterion 3D ball.png
|ImageSize1=230px | ImageSize1 = 240px
|ImageName1=Ball-and-stick model
| ImageAlt1=Ball-and-stick model of the cystathionine molecule as a zwitterion
|IUPACName=2-amino-4-(2-amino-2-carboxy-ethyl) thio-butanoic acid
|OtherNames=<small>L</small>-Cystathionine; ''S''--<small>L</small>-homocysteine | IUPACName=S-((R)-2-amino-2-carboxyethyl)-L-homocysteine
| OtherNames=<small>L</small>-Cystathionine; ''S''--<small>L</small>-homocysteine
|Section1= {{Chembox Identifiers |Section1={{Chembox Identifiers
| KEGG_Ref = {{keggcite|correct|kegg}} | KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = C00542 | KEGG = C00542
| InChI = 1/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13) | InChI = 1/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)
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| ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 209241 | ChEMBL = 209241
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI_Ref = {{stdinchicite|changed|chemspider}}
| StdInChI = 1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13) | StdInChI = 1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5-/m0/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
| StdInChIKey = ILRYLPWNYFXEMH-UHFFFAOYSA-N | StdInChIKey = ILRYLPWNYFXEMH-WHFBIAKZSA-N
| CASNo_Ref = {{cascite|correct|CAS}} | CASNo_Ref = {{cascite|correct|CAS}}
| CASNo=56-88-2 | CASNo=56-88-2
| UNII_Ref = {{fdacite|correct|FDA}}
| PubChem=834
| UNII = 375YFJ481O
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| PubChem=439258
| ChemSpiderID = 811
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChEBI = 17755
| ChemSpiderID = 388392
| SMILES = O=C(O)C(N)CSCCC(C(=O)O)N
| ChEBI_Ref = {{ebicite|correct|EBI}}
| MeSHName=Cystathionine
| ChEBI = 17755
| SMILES = C(CSC(C(=O)O)N)(C(=O)O)N
| MeSHName=Cystathionine
}} }}
|Section2= {{Chembox Properties |Section2={{Chembox Properties
| C=7|H=14|N=2|O=4|S=1
| Formula=C<sub>7</sub>H<sub>14</sub>N<sub>2</sub>O<sub>4</sub>S
| Appearance=
| MolarMass=222.263 g/mol
| Appearance= | Density=
| Density= | MeltingPt=
| MeltingPt= | BoilingPt=
| BoilingPt= | Solubility=
| Solubility=
}} }}
|Section3= {{Chembox Hazards |Section3={{Chembox Hazards
| MainHazards= | MainHazards=
| FlashPt= | FlashPt=
| AutoignitionPt =
| Autoignition=
}} }}
}} }}
'''Cystathionine''' is an intermediate in the synthesis of ].


It is generated from ] and serine by ]. '''Cystathionine''' is an intermediate in the synthesis of ] from ]. It is produced by the ] and is converted into cysteine by ] (CTH).


It is cleaved into ] and ] by ]. Biosynthetically, cystathionine is generated from ] and ] by ] (upper reaction in the diagram below). It is then cleaved into ] and ] by ] (lower reaction).


An excess in the urine is called ]. An excess of cystathionine in the urine is called ].


] catalyzes the upper reaction and ] catalyzes the lower reaction.]] ] catalyzes the upper reaction and ] catalyzes the lower reaction.]]{{clear-left}}


] (CDO), and ] can turn cysteine into ] and then ].<ref>{{ Cite journal | author = Harris Ripps, Wen Shen |date = 2012 | title = Review: Taurine: A "very essential" amino acid | journal = Molecular Vision |volume = 18 | pages = 2673–2686 | pmid=23170060 | pmc=3501277}}</ref> Alternately, the cysteine from the cystathionine gamma-lyase can be used by the enzymes ] (GCL) and ] (GSS) to produce ].
{{Amino acid metabolism intermediates}}


==References==
{{Reflist}}


{{Amino acid metabolism intermediates}}


]
{{biochem-stub}}

] ]
]

]
]
]
]