Revision as of 19:29, 7 August 2011 editBeetstra (talk | contribs)Edit filter managers, Administrators172,031 edits Script assisted update of identifiers for the Chem/Drugbox validation project (updated: 'ChEBI').← Previous edit |
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{{chembox |
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{{chembox |
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| Verifiedfields = changed |
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| verifiedrevid = 414094014 |
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| Watchedfields = changed |
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| verifiedrevid = 443553935 |
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| ImageFile_Ref = {{chemboximage|correct|??}} |
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| ImageFile_Ref = {{chemboximage|correct|??}} |
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| ImageFile=Cystathionine.png |
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| ImageFile = Cystathionin.svg |
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| ImageSize = 220 |
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|ImageName=Skeletal formula |
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| ImageAlt = Skeletal formula of cystathionine |
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|ImageFile1=Cystathionine-3D-balls.png |
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| ImageFile1 = Cystathionine zwitterion 3D ball.png |
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|ImageSize1=230px |
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| ImageSize1 = 240px |
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|ImageName1=Ball-and-stick model |
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| ImageAlt1=Ball-and-stick model of the cystathionine molecule as a zwitterion |
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|IUPACName=2-amino-4-(2-amino-2-carboxy-ethyl) thio-butanoic acid |
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|OtherNames=<small>L</small>-Cystathionine; ''S''--<small>L</small>-homocysteine |
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| IUPACName=S-((R)-2-amino-2-carboxyethyl)-L-homocysteine |
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| OtherNames=<small>L</small>-Cystathionine; ''S''--<small>L</small>-homocysteine |
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|Section1= {{Chembox Identifiers |
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|Section1={{Chembox Identifiers |
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| KEGG_Ref = {{keggcite|correct|kegg}} |
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| KEGG_Ref = {{keggcite|correct|kegg}} |
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| KEGG = C00542 |
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| KEGG = C00542 |
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| InChI = 1/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13) |
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| InChI = 1/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13) |
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| ChEMBL_Ref = {{ebicite|correct|EBI}} |
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| ChEMBL_Ref = {{ebicite|correct|EBI}} |
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| ChEMBL = 209241 |
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| ChEMBL = 209241 |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChI_Ref = {{stdinchicite|changed|chemspider}} |
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| StdInChI = 1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13) |
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| StdInChI = 1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)/t4-,5-/m0/s1 |
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| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} |
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| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} |
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| StdInChIKey = ILRYLPWNYFXEMH-UHFFFAOYSA-N |
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| StdInChIKey = ILRYLPWNYFXEMH-WHFBIAKZSA-N |
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| CASNo_Ref = {{cascite|correct|CAS}} |
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| CASNo_Ref = {{cascite|correct|CAS}} |
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| CASNo=56-88-2 |
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| CASNo=56-88-2 |
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| UNII_Ref = {{fdacite|correct|FDA}} |
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| PubChem=834 |
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| UNII = 375YFJ481O |
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| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} |
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| PubChem=439258 |
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| ChemSpiderID = 811 |
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| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} |
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| ChEBI = 17755 |
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| ChemSpiderID = 388392 |
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| SMILES = O=C(O)C(N)CSCCC(C(=O)O)N |
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| ChEBI_Ref = {{ebicite|correct|EBI}} |
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| MeSHName=Cystathionine |
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| ChEBI = 17755 |
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| SMILES = C(CSC(C(=O)O)N)(C(=O)O)N |
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| MeSHName=Cystathionine |
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}} |
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}} |
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|Section2= {{Chembox Properties |
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|Section2={{Chembox Properties |
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| C=7|H=14|N=2|O=4|S=1 |
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| Formula=C<sub>7</sub>H<sub>14</sub>N<sub>2</sub>O<sub>4</sub>S |
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| Appearance= |
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| MolarMass=222.263 g/mol |
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| Appearance= |
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| Density= |
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| Density= |
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| MeltingPt= |
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| Solubility= |
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| Solubility= |
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}} |
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}} |
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|Section3= {{Chembox Hazards |
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|Section3={{Chembox Hazards |
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| MainHazards= |
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| FlashPt= |
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| FlashPt= |
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| AutoignitionPt = |
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| Autoignition= |
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}} |
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}} |
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'''Cystathionine''' is an intermediate in the synthesis of ]. |
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It is generated from ] and serine by ]. |
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'''Cystathionine''' is an intermediate in the synthesis of ] from ]. It is produced by the ] and is converted into cysteine by ] (CTH). |
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It is cleaved into ] and ] by ]. |
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Biosynthetically, cystathionine is generated from ] and ] by ] (upper reaction in the diagram below). It is then cleaved into ] and ] by ] (lower reaction). |
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An excess in the urine is called ]. |
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An excess of cystathionine in the urine is called ]. |
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] catalyzes the upper reaction and ] catalyzes the lower reaction.]] |
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] catalyzes the upper reaction and ] catalyzes the lower reaction.]]{{clear-left}} |
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] (CDO), and ] can turn cysteine into ] and then ].<ref>{{ Cite journal | author = Harris Ripps, Wen Shen |date = 2012 | title = Review: Taurine: A "very essential" amino acid | journal = Molecular Vision |volume = 18 | pages = 2673–2686 | pmid=23170060 | pmc=3501277}}</ref> Alternately, the cysteine from the cystathionine gamma-lyase can be used by the enzymes ] (GCL) and ] (GSS) to produce ]. |
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{{Amino acid metabolism intermediates}} |
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==References== |
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{{Reflist}} |
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{{Amino acid metabolism intermediates}} |
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] |
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{{biochem-stub}} |
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] |
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] |
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] |
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] |
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] |
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] |
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] |
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